Sigma opiates and certain antipsychotic drugs mutually inhibit (+)-[3H] SKF 10,047 and [3H] haloperidol binding in guinea pig brain membranes.

SW Tam, L Cook - Proceedings of the National Academy of …, 1984 - National Acad Sciences
The relationship between binding of antipsychotic drugs and sigma psychotomimetic opiates
to binding sites for the sigma agonist (+)-[3H]SKF 10,047 (N-allylnormetazocine) and to …

A mathematical index of performance on fixed-interval schedules of reinforcement

W Fry, RT Kelleher, L Cook - Journal of the experimental analysis …, 1960 - ncbi.nlm.nih.gov
(Oa', a'b', b'c', and c' Y). Inspection of Fig. 1 indicates that the sum of the areas under Page 1 A
MATHEMATICAL INDEX OF PERFORMANCE ON FIXED-INTERVAL SCHEDULES OF …

Effects of various centrally acting drugs on fighting behavior of mice

RE Tedeschi, DH Tedeschi, A Mucha, L Cook… - … of Pharmacology and …, 1959 - ASPET
Fighting episodes were produced in mice by exposing the animals to a mild footshock. This
method permitted the objective measurement of the frequency of discrete fighting episodes …

[PDF][PDF] Effects of drugs on avoidance and escape behavior

L Cook, AC Catania - Fed. Proc, 1964 - researchgate.net
This discussion deals with the effects of drugs on avoidance and escape behavior and the
relationship of these effects to the effects on other behaviors. It is not intended as a review of …

Sesquiterpene lactone composition of wild and cultivated sunflowers and biological activity against an insect pest

JR Prasifka, O Spring, J Conrad, LW Cook… - Journal of agricultural …, 2015 - ACS Publications
Sesquiterpene lactones in sunflowers, Helianthus spp., are important to interactions with
pathogens, weeds, and insects. Across a broad range of Helianthus annuus, differences in …

Novel piperidine. sigma. receptor ligands as potential antipsychotic drugs

PJ Gilligan, GA Cain, TE Christos, L Cook… - Journal of medicinal …, 1992 - ACS Publications
receptor ligands represent a new class of potential antipsychotic drugs. This paper presents
the structure-activity relationships leading to novel disubstituted piperidine ligands, which …

Observing responses in pigeons

RT Kelleher, WC Riddle, L Cook - Journal of the Experimental …, 1962 - Wiley Online Library
Pigeons were trained on an observing‐response procedure in which periods of VR 100 and
EXT alternated unpredictably during a white light (mixed stimulus). During VR 100, …

Behavioral pharmacology of antianxiety drugs

J Sepinwall, L Cook - … of Psychopharmacology: Volume 13 Biology of …, 1978 - Springer
The discovery and introduction of valuable new antianxiety agents into clinical psychotherapeutics
within the last 20 years was accompanied by a parallel advance in the development …

DuP 996 (3, 3‐bis (4‐pyrindinylmethyl)‐1‐phenylindolin‐2‐one) enhances the stimulus‐induced release of acetylcholine from rat brain in vitro and in vivo

…, S William Tam, MJ Myers, L Cook - Drug development …, 1990 - Wiley Online Library
DuP 996, in micromolar concentrations, enhances the K + ‐stimulated release of acetylcholine
(ACh) in rat cerebral cortex, hippocampus, and caudate nucleus slices in vitro, without …

Some Pharmacological Observations on Tranylcypromine (SKF trans-385); A Potent Inhibitor of Monoamine Oxidase.

…, DH Tedeschi, PL Ames, L Cook… - Proceedings of the …, 1959 - journals.sagepub.com
Treatment of rabbits with tranylcypromine followed by the injection of reserpine produces
central nervous system stimulation and a marked rise in rectal temperature. The effects …