Interactions of glutathione transferases with 4-hydroxynonenal

LM Balogh, WM Atkins - Drug metabolism reviews, 2011 - Taylor & Francis
Electrophilic products of lipid peroxidation are important contributors to the progression of
several pathological states. The prototypical α,β–unsaturated aldehyde, 4-hydroxynonenal (…

Characterization of organic anion transporting polypeptide (OATP) expression and its functional contribution to the uptake of substrates in human hepatocytes

E Kimoto, K Yoshida, LM Balogh, Y Bi… - Molecular …, 2012 - ACS Publications
Since the substrate specificities of OATP1B1, 1B3, and 2B1 are broad and overlapping, the
contribution of each isoform to the overall hepatic uptake is of concern when assessing …

[HTML][HTML] Functional promiscuity correlates with conformational heterogeneity in A-class glutathione S-transferases

L Hou, MT Honaker, LM Shireman, LM Balogh… - Journal of biological …, 2007 - ASBMB
The structurally related glutathione S-transferase isoforms GSTA1-1 and GSTA4-4 differ
greatly in their relative catalytic promiscuity. GSTA1-1 is a highly promiscuous detoxification …

Absolute measurement of species differences in sodium taurocholate cotransporting polypeptide (NTCP/Ntcp) and its modulation in cultured hepatocytes

X Qiu, YA Bi, LM Balogh, Y Lai - Journal of pharmaceutical sciences, 2013 - Elsevier
Species differences among membrane transporters can be remarkable and difficult to
properly assess by conventional methods. Herein, we employed the first use of stable isotope …

Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal

LM Balogh, I Le Trong, KA Kripps, LM Shireman… - Biochemistry, 2010 - ACS Publications
Conjugation to glutathione (GSH) by glutathione transferase A4-4 (GSTA4-4) is a major route
of elimination for the lipid peroxidation product 4-hydroxynonenal (HNE), a toxic compound …

Mechanism-based inactivation of cytochrome P450 2C9 by tienilic acid and (±)-suprofen: a comparison of kinetics and probe substrate selection

JM Hutzler, LM Balogh, M Zientek, V Kumar… - Drug metabolism and …, 2009 - ASPET
In vitro experiments were conducted to compare k inact , K I and inactivation efficiency (k
inact /K I ) of cytochrome P450 (P450) 2C9 by tienilic acid and (±)-suprofen using (S)-…

[HTML][HTML] The stereochemical course of 4-hydroxy-2-nonenal metabolism by glutathione S-transferases

LM Balogh, AG Roberts, LM Shireman… - Journal of biological …, 2008 - ASBMB
4-Hydroxy-2-nonenal (HNE) is a toxic aldehyde generated during lipid peroxidation and
has been implicated in a variety of pathological states associated with oxidative stress. …

Preclinical and clinical evidence for the collaborative transport and renal secretion of an oxazolidinone antibiotic by organic anion transporter 3 (OAT3/SLC22A8) and …

Y Lai, KE Sampson, LM Balogh, TG Brayman… - … of Pharmacology and …, 2010 - ASPET
N-({(5S)-3-[4-(1,1-dioxidothiomorpholin-4-yl)-3,5-difluorophenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide
(PNU-288034), an oxazolidinone antibiotic, was terminated in phase I …

Structural analysis of a glutathione transferase A1-1 mutant tailored for high catalytic efficiency with toxic alkenals

LM Balogh, I Le Trong, KA Kripps, K Tars… - Biochemistry, 2009 - ACS Publications
The specificity of human glutathione transferase (GST) A1-1 is drastically altered to favor
alkenal substrates in the GIMFhelix mutant designed to mimic first-sphere interactions utilized …

Glutathione transferase A4-4 resists adduction by 4-hydroxynonenal

LM Shireman, KA Kripps, LM Balogh, KP Conner… - Archives of biochemistry …, 2010 - Elsevier
4-Hydroxy-2-trans-nonenal (HNE) is a lipid peroxidation product that contributes to the
pathophysiology of several diseases with components of oxidative stress. The electrophilic nature …