Interactions of glutathione transferases with 4-hydroxynonenal
LM Balogh, WM Atkins - Drug metabolism reviews, 2011 - Taylor & Francis
Electrophilic products of lipid peroxidation are important contributors to the progression of
several pathological states. The prototypical α,β–unsaturated aldehyde, 4-hydroxynonenal (…
several pathological states. The prototypical α,β–unsaturated aldehyde, 4-hydroxynonenal (…
Characterization of organic anion transporting polypeptide (OATP) expression and its functional contribution to the uptake of substrates in human hepatocytes
E Kimoto, K Yoshida, LM Balogh, Y Bi… - Molecular …, 2012 - ACS Publications
Since the substrate specificities of OATP1B1, 1B3, and 2B1 are broad and overlapping, the
contribution of each isoform to the overall hepatic uptake is of concern when assessing …
contribution of each isoform to the overall hepatic uptake is of concern when assessing …
[HTML][HTML] Functional promiscuity correlates with conformational heterogeneity in A-class glutathione S-transferases
L Hou, MT Honaker, LM Shireman, LM Balogh… - Journal of biological …, 2007 - ASBMB
The structurally related glutathione S-transferase isoforms GSTA1-1 and GSTA4-4 differ
greatly in their relative catalytic promiscuity. GSTA1-1 is a highly promiscuous detoxification …
greatly in their relative catalytic promiscuity. GSTA1-1 is a highly promiscuous detoxification …
Absolute measurement of species differences in sodium taurocholate cotransporting polypeptide (NTCP/Ntcp) and its modulation in cultured hepatocytes
Species differences among membrane transporters can be remarkable and difficult to
properly assess by conventional methods. Herein, we employed the first use of stable isotope …
properly assess by conventional methods. Herein, we employed the first use of stable isotope …
Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal
LM Balogh, I Le Trong, KA Kripps, LM Shireman… - Biochemistry, 2010 - ACS Publications
Conjugation to glutathione (GSH) by glutathione transferase A4-4 (GSTA4-4) is a major route
of elimination for the lipid peroxidation product 4-hydroxynonenal (HNE), a toxic compound …
of elimination for the lipid peroxidation product 4-hydroxynonenal (HNE), a toxic compound …
Mechanism-based inactivation of cytochrome P450 2C9 by tienilic acid and (±)-suprofen: a comparison of kinetics and probe substrate selection
JM Hutzler, LM Balogh, M Zientek, V Kumar… - Drug metabolism and …, 2009 - ASPET
In vitro experiments were conducted to compare k inact , K I and inactivation efficiency (k
inact /K I ) of cytochrome P450 (P450) 2C9 by tienilic acid and (±)-suprofen using (S)-…
inact /K I ) of cytochrome P450 (P450) 2C9 by tienilic acid and (±)-suprofen using (S)-…
[HTML][HTML] The stereochemical course of 4-hydroxy-2-nonenal metabolism by glutathione S-transferases
LM Balogh, AG Roberts, LM Shireman… - Journal of biological …, 2008 - ASBMB
4-Hydroxy-2-nonenal (HNE) is a toxic aldehyde generated during lipid peroxidation and
has been implicated in a variety of pathological states associated with oxidative stress. …
has been implicated in a variety of pathological states associated with oxidative stress. …
Preclinical and clinical evidence for the collaborative transport and renal secretion of an oxazolidinone antibiotic by organic anion transporter 3 (OAT3/SLC22A8) and …
Y Lai, KE Sampson, LM Balogh, TG Brayman… - … of Pharmacology and …, 2010 - ASPET
N-({(5S)-3-[4-(1,1-dioxidothiomorpholin-4-yl)-3,5-difluorophenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide
(PNU-288034), an oxazolidinone antibiotic, was terminated in phase I …
(PNU-288034), an oxazolidinone antibiotic, was terminated in phase I …
Structural analysis of a glutathione transferase A1-1 mutant tailored for high catalytic efficiency with toxic alkenals
LM Balogh, I Le Trong, KA Kripps, K Tars… - Biochemistry, 2009 - ACS Publications
The specificity of human glutathione transferase (GST) A1-1 is drastically altered to favor
alkenal substrates in the GIMFhelix mutant designed to mimic first-sphere interactions utilized …
alkenal substrates in the GIMFhelix mutant designed to mimic first-sphere interactions utilized …
Glutathione transferase A4-4 resists adduction by 4-hydroxynonenal
LM Shireman, KA Kripps, LM Balogh, KP Conner… - Archives of biochemistry …, 2010 - Elsevier
4-Hydroxy-2-trans-nonenal (HNE) is a lipid peroxidation product that contributes to the
pathophysiology of several diseases with components of oxidative stress. The electrophilic nature …
pathophysiology of several diseases with components of oxidative stress. The electrophilic nature …