Methylene blue or other redox dyes are extensively used as indicators of dehydrogenases.
Enzyme activities are frequently defined by the anaerobic decolorization time of a redox dye, …

A variety of pharmacologic, behavioral, and receptor-binding studies were performed in an
effort to determine the mechanism and site of action of nicotine on the rat brain. When …

Human granulocytes and monocytes exhibited stereospecific, high-affinity binding to 3-quinuclidinyl
benzilate (QNB) and dihydromorphine (DHM), specific ligands for the muscarinic …

The main purpose of the present work was to study in detail the outflux of P 32 from excitable
tissues accompanying membrane depolarization or electrical excitation. With the use of P …

The semirigid alkaloid anatoxin a (3) 3 is known to possess high activity at the nicotinic
acetylcholine receptor. 4 Nornicotine (la), a potent agonist in its own right, has an activity …

Chlorpromazine uncoupled the oxidative phosphorylation of brain mitochondria and
inhibited cytochrome oxidase in concentrations not affecting overall oxidation. Since the drug …

The recently discovered nicotinic agonist pyrido [3, 4-b] homotropane (PHT) as well as its N-methyl
and 2'-meihyl derivatives (syntheses reported herein) were compared with nicotine, …

Publisher Summary The chapter discusses anticholonergic psychotomimetic agents and
emphasizes on the structure-activity relationships of this class of agents as well as upon their …

Publisher Summary This chapter describes the methodological approach, thermodynamic
considerations of P efflux, depolarization and phosphorylation, relationship of P efflux to P …

The structure–activity relationships were established for nicotine analogs and related agents
comparing their competition for [ 3 H]nicotine binding to rat brain membranes, Torpedo …