N-(2-Benzoylphenyl)-l-tyrosine PPARγ Agonists. 1. Discovery of a Novel Series of Potent Antihyperglycemic and Antihyperlipidemic Agents
…, JM Lenhard, LA Orband-Miller… - Journal of medicinal …, 1998 - ACS Publications
We have identified a novel series of antidiabetic N-(2-benzoylphenyl)-l-tyrosine derivatives
which are potent, selective PPARγ agonists. Through the use of in vitro PPARγ binding and …
which are potent, selective PPARγ agonists. Through the use of in vitro PPARγ binding and …
[HTML][HTML] Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells
…, J Jing, H Lu, JE McSurdy-Freed, LA Orband-Miller… - Cancer & …, 2013 - Springer
Background Most normal cells in the presence of oxygen utilize glucose for mitochondrial
oxidative phosphorylation. In contrast, many cancer cells rapidly convert glucose to lactate in …
oxidative phosphorylation. In contrast, many cancer cells rapidly convert glucose to lactate in …
A new series of estrogen receptor modulators that display selectivity for estrogen receptor β
…, LB Moore, JT Moore, LA Orband-Miller… - Journal of medicinal …, 2002 - ACS Publications
A series of 1,3,5-triazine-based estrogen receptor (ER) modulators that are modestly selective
for the ERβ subtype are reported. Compound 1, which displayed modest potency and …
for the ERβ subtype are reported. Compound 1, which displayed modest potency and …
Pharmacologic inhibition of RORγt regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivo
…, T Carlson, J Hill, LA Orband-Miller… - The Journal of …, 2014 - journals.aai.org
IL-17–producing CD4+ Th17 cells, CD8+ Tc17 cells, and γδ T cells play critical roles in the
pathogenesis of autoimmune psoriasis. RORγt is required for the differentiation of Th17 cells …
pathogenesis of autoimmune psoriasis. RORγt is required for the differentiation of Th17 cells …
GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα
…, JL Collins, DJ Parks, LA Orband-Miller… - ACS chemical …, 2010 - ACS Publications
The identification of nonporphyrin ligands for the orphan nuclear receptor Rev-erbα will
enable studies of its role as a heme sensor and regulator of metabolic and circadian signaling. …
enable studies of its role as a heme sensor and regulator of metabolic and circadian signaling. …
[PDF][PDF] Effects of prenatal nicotine exposure on biochemical development of rat brain regions: maternal drug infusions via osmotic minipumps.
TA Slotkin, L Orband-Miller, KL Queen… - … of Pharmacology and …, 1987 - Citeseer
The effects of a continuous 16-day gestational exposure to nicotine on brain development
were examined in the offspring of dams who received a minipump implant on the 4th day of …
were examined in the offspring of dams who received a minipump implant on the 4th day of …
[HTML][HTML] X-ray crystal structures of the estrogen-related receptor-γ ligand binding domain in three functional states reveal the molecular basis of small molecule …
…, MH Lambert, AB Miller, LA Orband-Miller… - Journal of Biological …, 2006 - ASBMB
X-ray crystal structures of the ligand binding domain (LBD) of the estrogen-related receptor-γ
(ERRγ) were determined that describe this receptor in three distinct states: unliganded, …
(ERRγ) were determined that describe this receptor in three distinct states: unliganded, …
Development of [3H] nicotine binding sites in brain regions of rats exposed to nicotine prenatally via maternal injections or infusions.
TA Slotkin, L Orband-Miller, KL Queen - Journal of Pharmacology and …, 1987 - ASPET
The fetal and postnatal development of binding sites for [3H]nicotine was examined in brain
regions of normal rats and rats whose mothers received nicotine injections or infusions, …
regions of normal rats and rats whose mothers received nicotine injections or infusions, …
Identification and structure− activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRβ and ERRγ
WJ Zuercher, S Gaillard, LA Orband-Miller… - Journal of medicinal …, 2005 - ACS Publications
The first small molecule agonists of the estrogen-related receptors have been identified.
GSK4716 (3) and GSK9089 (4) show binding to ERRγ with remarkable selectivity over the …
GSK4716 (3) and GSK9089 (4) show binding to ERRγ with remarkable selectivity over the …
Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRγ
…, S Gaillard, AB Miller, L Wang, LA Orband-Miller… - Bioorganic & medicinal …, 2006 - Elsevier
The design and synthesis of 4-hydroxytamoxifen (4-OHT) derivatives are described. The
binding affinities of these compounds toward the orphan estrogen-related receptor γ and the …
binding affinities of these compounds toward the orphan estrogen-related receptor γ and the …