[HTML][HTML] Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)

X Xu, KL Poulsen, L Wu, S Liu, T Miyata… - Signal transduction and …, 2022 - nature.com
Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive and …

MLKL-dependent signaling regulates autophagic flux in a murine model of non-alcohol-associated fatty liver and steatohepatitis

X Wu, KL Poulsen, C Sanz-Garcia, E Huang… - Journal of …, 2020 - Elsevier
Background & Aims Autophagy maintains cellular homeostasis and plays a critical role in
the development of non-alcoholic fatty liver and steatohepatitis. The pseudokinase mixed …

Hepatic recruitment of eosinophils and their protective function during acute liver injury

…, C Emontzpohl, CL Atkins, Z Sun, KL Poulsen… - Journal of …, 2022 - Elsevier
Background & Aims Beyond the classical description of eosinophil functions in parasite
infections and allergic diseases, emerging evidence supports a critical role of eosinophils in …

Gut microbial trimethylamine is elevated in alcohol-associated hepatitis and contributes to ethanol-induced liver injury in mice

…, RC Schugar, MR McMullen, A Bellar, KL Poulsen… - Elife, 2022 - elifesciences.org
There is mounting evidence that microbes residing in the human intestine contribute to
diverse alcohol-associated liver diseases (ALD) including the most deadly form known as …

The effects of obesity and metabolic abnormalities on severe COVID-19-related outcomes after vaccination: A population-based study

…, Y Shi, Z Wang, Z Yao, P Lu, T Liu, Q Li, KL Poulsen… - Cell Metabolism, 2023 - cell.com
Breakthrough SARS-CoV-2 infections of vaccinated individuals are being reported globally,
resulting in an increased risk of hospitalization and death among such patients. Therefore, it …

CD73-dependent adenosine signaling through Adora2b drives immunosuppression in ductal pancreatic cancer

…, JS Bynon, CJ Wray, D Bar-Sagi, KL Poulsen… - Cancer research, 2023 - AACR
Ductal-derived pancreatic tumors have elevated epithelial and CD8 + GZM + T-cell CD73
expression that confers sensitivity to small-molecule inhibition of CD73 or Adora2b to promote …

Radiofrequency ablation remodels the tumor microenvironment and promotes neutrophil-mediated abscopal immunomodulation in pancreatic cancer

…, P Cen, J Rowe, J Cardenas, KL Poulsen… - Cancer immunology …, 2023 - AACR
… Scale bars are 50 μmol/L. … Scale bars are 50 μmol/L. … KL Poulsen is funded by
R00AA026648. …

[HTML][HTML] Effect of acid suppressants on the risk of COVID-19: a propensity score-matched study using UK Biobank

…, S Dasarathy, DM Rotroff, X Wu, KL Poulsen… - …, 2021 - ncbi.nlm.nih.gov
Methods The study included 9469 participants who had been tested for COVID-19 from
March 16 to June 29, 2020, in UK Biobank. 7 Medication data on UK Biobank patients were …

[HTML][HTML] Alcohol consumption is associated with poor prognosis in obese patients with COVID-19: a Mendelian randomization study using UK Biobank

X Fan, Z Liu, KL Poulsen, X Wu, T Miyata, S Dasarathy… - Nutrients, 2021 - mdpi.com
Background: Acute and chronic alcohol abuse has adverse impacts on both the innate and
adaptive immune response, which may result in reduced resistance to severe acute …

[HTML][HTML] Aryl hydrocarbon receptor maintains hepatic mitochondrial homeostasis in mice

MJ Heo, JH Suh, SH Lee, KL Poulsen, YA An… - Molecular …, 2023 - Elsevier
Objective Mitophagy removes damaged mitochondria to maintain cellular homeostasis. Aryl
hydrocarbon receptor (AhR) expression in the liver plays a crucial role in supporting normal …