Regulation of the dopamine transporter: aspects relevant to psychostimulant drugs of abuse

KC Schmitt, MEA Reith - Annals of the New York Academy of …, 2010 - Wiley Online Library
Dopaminergic signaling in the brain is primarily modulated by dopamine transporters (DATs),
which actively translocate extraneuronal dopamine back into dopaminergic neurons. …

[HTML][HTML] The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors

KC Schmitt, MEA Reith - PloS one, 2011 - journals.plos.org
Modafinil is a mild psychostimulant with pro-cognitive and antidepressant effects. Unlike
many conventional stimulants, modafinil has little appreciable potential for abuse, making it a …

PhMYB4 fine-tunes the floral volatile signature of Petunia×hybrida through PhC4H

…, AE Wedde, LA Levin, KC Schmitt… - Journal of …, 2011 - academic.oup.com
In Petunia×hybrida cv ‘Mitchell Diploid’ (MD), floral volatile benzenoid/phenylpropanoid (FVBP)
biosynthesis is controlled spatially, developmentally, and daily at molecular, metabolic, …

Behavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporter

…, BE Blough, WC Hong, KT Jones, KC Schmitt… - Drug and alcohol …, 2015 - Elsevier
Background Treatment of stimulant-use disorders remains a formidable challenge, and the
dopamine transporter (DAT) remains a potential target for antagonist or agonist-like …

Nonclassical pharmacology of the dopamine transporter: atypical inhibitors, allosteric modulators, and partial substrates

KC Schmitt, RB Rothman, MEA Reith - Journal of Pharmacology and …, 2013 - ASPET
The dopamine transporter (DAT) is a sodium-coupled symporter protein responsible for
modulating the concentration of extraneuronal dopamine in the brain. The DAT is a principle …

Interaction of cocaine‐, benztropine‐, and GBR12909‐like compounds with wild‐type and mutant human dopamine transporters: molecular features that differentially …

KC Schmitt, J Zhen, P Kharkar, M Mishra… - Journal of …, 2008 - Wiley Online Library
The widely abused psychostimulant cocaine is thought to elicit its reinforcing effects primarily
via inhibition of the neuronal dopamine transporter (DAT). However, not all DAT inhibitors …

Bivalent phenethylamines as novel dopamine transporter inhibitors: evidence for multiple substrate‐binding sites in a single transporter

KC Schmitt, S Mamidyala, S Biswas… - Journal of …, 2010 - Wiley Online Library
Bivalent phenethylamines as novel dopamine transporter inhibitors: evidence for multiple
substrate‐binding sites in a single transporter - Schmitt - 2010 - Journal of Neurochemistry - …

Novel C-1 substituted cocaine analogs unlike cocaine or benztropine

…, NV Gaddiraju, S Mehrotra, KC Schmitt… - … of Pharmacology and …, 2012 - ASPET
Despite a wealth of information on cocaine-like compounds, there is no information on
cocaine analogs with substitutions at C-1. Here, we report on (R)-(−)-cocaine analogs with …

Tamoxifen directly interacts with the dopamine transporter

SR Mikelman, B Guptaroy, KC Schmitt, KT Jones… - … of Pharmacology and …, 2018 - ASPET
The selective estrogen receptor modulator tamoxifen increases extracellular dopamine in
vivo and acts as a neuroprotectant in models of dopamine neurotoxicity. We investigated the …

[PDF][PDF] Experiments on Optimization of Corn and Sweet Corn Production Through Cultural Practices in Eastern North Carolina.

KC Schmitt - 2013 - repository.lib.ncsu.edu
… temperature of 35 o C, and another growth chamber was maintained at a temperature of
10 … by Kyle Schmitt … My name is Kyle Schmitt. I grew up in the panhandle of Florida. I …