The embryonic role of endothelial cells and nascent vessels in promoting organogenesis,
prior to vascular function, is unclear. We find that early endothelial cells in mouse embryos …

Liver cirrhosis is the irreversible end result of fibrous scarring and hepatocellular regeneration,
characterized by diffuse disorganization of the normal hepatic structure of regenerative …

Specific tissue interactions between epithelia and mesenchyme (or stroma), eg, epithelial-mesenchymal
(or -stromal) interactions mediate crucial aspects of normal development and …

Lung cancer with epidermal growth factor receptor (EGFR)–activating mutations responds
favorably to the EGFR tyrosine kinase inhibitors gefitinib and erlotinib. However, 25% to 30% …

Using a rat model of ischemia/reperfusion injury, we demonstrate here that HGF is
cardioprotective due to its antiapoptotic effect on cardiomyocytes. Following transient myocardial …

Radiotherapy represents a major treatment option for patients with pancreatic cancer, but
recent evidence suggests that radiation can promote invasion and metastasis of cancer cells. …

Signaling driven by hepatocyte growth factor ( HGF ) and MET receptor facilitates conspicuous
biological responses such as epithelial cell migration, 3‐D morphogenesis, and survival. …

Activation of hepatocyte growth factor (HGF) by proteolytic processing is triggered in cancer
microenvironments, and subsequent signaling through the MET receptor is involved in …

We prepared a specific antagonist for hepatocyte growth factor (HGF) and designated it HGF/NK4.
HGF/NK4 is composed of N-terminal 447 amino acids of the α-chain of HGF, thus …

Liver regeneration depends on the proliferation of mature hepatocytes. In the 1980s, the
method for the cultivation of mature hepatocytes provided an opportunity for the discovery of …