Liver organogenesis promoted by endothelial cells prior to vascular function
The embryonic role of endothelial cells and nascent vessels in promoting organogenesis,
prior to vascular function, is unclear. We find that early endothelial cells in mouse embryos …
prior to vascular function, is unclear. We find that early endothelial cells in mouse embryos …
Hepatocyte growth factor gene therapy of liver cirrhosis in rats
…, K Nakanishi, Y Sawa, R Morishita, K Matsumoto… - Nature medicine, 1999 - nature.com
Liver cirrhosis is the irreversible end result of fibrous scarring and hepatocellular regeneration,
characterized by diffuse disorganization of the normal hepatic structure of regenerative …
characterized by diffuse disorganization of the normal hepatic structure of regenerative …
Emerging multipotent aspects of hepatocyte growth factor
K Matsumoto, T Nakamura - The journal of biochemistry, 1996 - academic.oup.com
Specific tissue interactions between epithelia and mesenchyme (or stroma), eg, epithelial-mesenchymal
(or -stromal) interactions mediate crucial aspects of normal development and …
(or -stromal) interactions mediate crucial aspects of normal development and …
Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor–activating mutations
S Yano, W Wang, QI Li, K Matsumoto, H Sakurama… - Cancer research, 2008 - AACR
Lung cancer with epidermal growth factor receptor (EGFR)–activating mutations responds
favorably to the EGFR tyrosine kinase inhibitors gefitinib and erlotinib. However, 25% to 30% …
favorably to the EGFR tyrosine kinase inhibitors gefitinib and erlotinib. However, 25% to 30% …
[HTML][HTML] Myocardial protection from ischemia/reperfusion injury by endogenous and exogenous HGF
T Nakamura, S Mizuno, K Matsumoto… - The Journal of …, 2000 - Am Soc Clin Investig
Using a rat model of ischemia/reperfusion injury, we demonstrate here that HGF is
cardioprotective due to its antiapoptotic effect on cardiomyocytes. Following transient myocardial …
cardioprotective due to its antiapoptotic effect on cardiomyocytes. Following transient myocardial …
Radiation to stromal fibroblasts increases invasiveness of pancreatic cancer cells through tumor-stromal interactions
…, M Murakami, LW Qian, N Sato, E Nagai, K Matsumoto… - Cancer research, 2004 - AACR
Radiotherapy represents a major treatment option for patients with pancreatic cancer, but
recent evidence suggests that radiation can promote invasion and metastasis of cancer cells. …
recent evidence suggests that radiation can promote invasion and metastasis of cancer cells. …
Hepatocyte growth factor/MET in cancer progression and biomarker discovery
K Matsumoto, M Umitsu, DM De Silva, A Roy… - Cancer …, 2017 - Wiley Online Library
Signaling driven by hepatocyte growth factor ( HGF ) and MET receptor facilitates conspicuous
biological responses such as epithelial cell migration, 3‐D morphogenesis, and survival. …
biological responses such as epithelial cell migration, 3‐D morphogenesis, and survival. …
Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor
…, S Yano, M Shibata, H Suga, K Matsumoto - Nature chemical …, 2019 - nature.com
Activation of hepatocyte growth factor (HGF) by proteolytic processing is triggered in cancer
microenvironments, and subsequent signaling through the MET receptor is involved in …
microenvironments, and subsequent signaling through the MET receptor is involved in …
[HTML][HTML] HGF/NK4 is a specific antagonist for pleiotrophic actions of hepatocyte growth factor
K Date, K Matsumoto, H Shimura, M Tanaka… - FEBS letters, 1997 - Elsevier
We prepared a specific antagonist for hepatocyte growth factor (HGF) and designated it HGF/NK4.
HGF/NK4 is composed of N-terminal 447 amino acids of the α-chain of HGF, thus …
HGF/NK4 is composed of N-terminal 447 amino acids of the α-chain of HGF, thus …
Hepatocyte growth factor twenty years on: Much more than a growth factor
…, K Sakai, T Nakamura, K Matsumoto - Journal of …, 2011 - Wiley Online Library
Liver regeneration depends on the proliferation of mature hepatocytes. In the 1980s, the
method for the cultivation of mature hepatocytes provided an opportunity for the discovery of …
method for the cultivation of mature hepatocytes provided an opportunity for the discovery of …