In the United States stroke is the third leading cause of death and the leading cause of
disability. Brain injury following stroke results from the complex interplay of multiple pathways …

Each year, 10 million people worldwide survive the neurologic injury associated with a
stroke. Importantly, stroke survivors have more than twice the risk of subsequently developing …

Background TGFβ is both neuroprotective and a key immune system modulator and is likely
to be an important target for future stroke therapy. The precise function of increased TGF-β1 …

Astrocytes limit inflammation after CNS injury, at least partially by physically containing it
within an astrocytic scar at the injury border. We report here that astrocytic transforming growth …

Background and Purpose— Mild hypothermia confers profound neuroprotection in ischemia.
We recently discovered 2 natural derivatives of thyroxine, 3-iodothyronamine (T 1 AM) and …

Following stroke, the damaged tissue undergoes liquefactive necrosis, a stage of infarct
resolution that lasts for months although the exact length of time is currently unknown. One …

Osteopontin (OPN), a large secreted glycoprotein with an arginine, glycine, aspartate (RGD)
motif, can bind and signal through cellular integrin receptors. We have shown previously …

Increasing evidence indicates that decreased brain blood flow, increased reactive oxygen
species (ROS) production, and proinflammatory mechanisms accelerate neurodegenerative …

This study provides a parallel characterization of the cytokine and chemokine response to
stroke in the human and mouse brain at different stages of infarct resolution. The study goal …

C57BL/6J are the most commonly used strain of mouse for stroke experiments but vascular
anatomy of the Circle of Willis within this strain is extremely variable and the cortex has …