Accumulation of plastic-derived chemicals in tissues of seabirds ingesting marine plastics
K Tanaka, H Takada, R Yamashita, K Mizukawa… - Marine pollution …, 2013 - Elsevier
We analyzed polybrominated diphenyl ethers (PBDEs) in abdominal adipose of oceanic
seabirds (short-tailed shearwaters, Puffinus tenuirostris) collected in northern North Pacific …
seabirds (short-tailed shearwaters, Puffinus tenuirostris) collected in northern North Pacific …
[PDF][PDF] Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM-and PUMA-mediated apoptosis
The clinical success of EGFR inhibitors in EGFR-mutant lung cancer is limited by the eventual
development of acquired resistance. We hypothesize that enhancing apoptosis through …
development of acquired resistance. We hypothesize that enhancing apoptosis through …
[HTML][HTML] Microplastic fragments and microbeads in digestive tracts of planktivorous fish from urban coastal waters
K Tanaka, H Takada - Scientific reports, 2016 - nature.com
We investigated microplastics in the digestive tracts of 64 Japanese anchovy (Engraulis
japonicus) sampled in Tokyo Bay. Plastic was detected in 49 out of 64 fish (77%), with 2.3 …
japonicus) sampled in Tokyo Bay. Plastic was detected in 49 out of 64 fish (77%), with 2.3 …
[HTML][HTML] Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors
…, H Kiyota, N Sriwilaijaroen, J Qi, K Tanaka… - Nature …, 2013 - nature.com
Abstract Development of novel influenza neuraminidase inhibitors is critical for preparedness
against influenza outbreaks. Knowledge of the neuraminidase enzymatic mechanism and …
against influenza outbreaks. Knowledge of the neuraminidase enzymatic mechanism and …
Facilitated leaching of additive-derived PBDEs from plastic by seabirds' stomach oil and accumulation in tissues
K Tanaka, H Takada, R Yamashita… - … science & technology, 2015 - ACS Publications
Our previous study suggested the transfer of polybrominated diphenyl ether (PBDE) flame
retardants from ingested plastics to seabirds’ tissues. To understand how the PBDEs are …
retardants from ingested plastics to seabirds’ tissues. To understand how the PBDEs are …
Rebiopsy of non–small cell lung cancer patients with acquired resistance to epidermal growth factor receptor‐tyrosine kinase inhibitor: comparison between t790m …
…, N Katakami, H Yoshioka, J Takeshita, K Tanaka… - Cancer, 2013 - Wiley Online Library
BACKGROUND The secondary epidermal growth factor receptor (EGFR) mutation Thr790Met
(T790M) accounts for approximately half of acquired resistances to EGFR‐tyrosine kinase …
(T790M) accounts for approximately half of acquired resistances to EGFR‐tyrosine kinase …
The CLIP1–LTK fusion is an oncogenic driver in non‐small‐cell lung cancer
H Izumi, S Matsumoto, J Liu, K Tanaka, S Mori… - Nature, 2021 - nature.com
Lung cancer is one of the most aggressive tumour types. Targeted therapies stratified by
oncogenic drivers have substantially improved therapeutic outcomes in patients with non-small-…
oncogenic drivers have substantially improved therapeutic outcomes in patients with non-small-…
Mechanical recycling of plastic waste as a point source of microplastic pollution
G Suzuki, N Uchida, K Tanaka, H Matsukami… - Environmental …, 2022 - Elsevier
Plastic pollution has become one of the most pressing environmental issues. Recycling is a
potential means of reducing plastic pollution in the environment. However, plastic fragments …
potential means of reducing plastic pollution in the environment. However, plastic fragments …
[PDF][PDF] Differential Crizotinib Response Duration Among ALK Fusion Variants in ALK-Positive Non–Small-Cell Lung Cancer
T Yoshida, Y Oya, K Tanaka… - Journal of Clinical …, 2016 - clf1.medpagetoday.com
Purpose Anaplastic lymphoma kinase (ALK) rearrangement–positive non–small-cell lung
cancers can be effectively treated with an ALK tyrosine kinase inhibitor (TKI) such as crizotinib, …
cancers can be effectively treated with an ALK tyrosine kinase inhibitor (TKI) such as crizotinib, …
[HTML][HTML] Endotoxins and non-alcoholic fatty liver disease
T Kessoku, T Kobayashi, K Imajo, K Tanaka… - Frontiers in …, 2021 - frontiersin.org
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide. It occurs with a prevalence of up to 25%, of which 10–20% cases progress to …
worldwide. It occurs with a prevalence of up to 25%, of which 10–20% cases progress to …