4-Benzylamino-1-chloro-6-substituted phthalazines: synthesis and inhibitory activity toward phosphodiesterase 5

…, K Miyazaki, H Ishihara, K Kodama… - Journal of medicinal …, 1998 - ACS Publications
We synthesized various 4-benzylamino-1-chloro-6-substituted phthalazines (15) and 4-benzylamino-1-chloro-7-substituted
phthalazines (16) and evaluated their inhibitory activity …

Effects of intravenous infusion of highly purified vitamin B2 on lipopolysaccharide-induced shock and bacterial infection in mice

T Toyosawa, M Suzuki, K Kodama, S Araki - European journal of …, 2004 - Elsevier
We investigated the effect of an iv infusion of highly purified vitamin B 2 (riboflavin 5′-sodium
phosphate: purity >97%) on lipopolysaccharide-induced shock and bacterial infection in …

Highly purified vitamin B2 presents a promising therapeutic strategy for sepsis and septic shock

T Toyosawa, M Suzuki, K Kodama… - Infection and immunity, 2004 - Am Soc Microbiol
Highly purified vitamin B2 (riboflavin 5′-sodium phosphate; purity > 97%) treatment by
intravenous infusion at doses above those used clinically to treat vitamin B2 deficiency showed …

Inhibitory mechanisms of highly purified vitamin B2 on the productions of proinflammatory cytokine and NO in endotoxin-induced shock in mice

K Kodama, M Suzuki, T Toyosawa, S Araki - Life sciences, 2005 - Elsevier
Inhibitory effects of highly purified vitamin B 2 (riboflavin-5′-sodium phosphate, >97%) on
the interleukin (IL)-6, macrophage inflammatory protein (MIP)-2 and nitric oxide (NO) in LPS-…

Potentiation by amino acid of the therapeutic effect of highly purified vitamin B2 in mice with lipopolysaccharide-induced shock

T Toyosawa, M Suzuki, K Kodama, S Araki - European journal of …, 2004 - Elsevier
The aim of this experiment was to clarify whether an amino acid supplement could enhance
the therapeutic effect of vitamin B 2 (riboflavin 5'-sodium phosphate; purity>97%) in mice …

4-(3-Chloro-4-methoxybenzyl) aminophthalazines: synthesis and inhibitory activity toward phosphodiesterase 5

…, K Ishibashi, H Ishihara, K Kodama… - Journal of medicinal …, 2000 - ACS Publications
We synthesized various 4-(3-chloro-4-methoxybenzyl)aminophthalazines substituted at the
1- and 6-positions and evaluated their inhibitory activity toward phosphodiesterase 5 (PDE5) …

Improvement of mortality by long-term E4010 treatment in monocrotaline-induced pulmonary hypertensive rats

K Kodama, H Adachi - Journal of Pharmacology and Experimental …, 1999 - ASPET
We investigated the effects of long-term treatment with a selective phosphodiesterase 5
inhibitor E4010, 4-(3-chloro-4methoxybenzyl)amino-1-(4-hydroxypiperidino)-6-…

Effects of a novel, selective and potent phosphodiesterase type V inhibitor, E4021, on myocardial ischemia in guinea pigs

K Kodama, H Adachi, N Mori, I Saito - European journal of pharmacology, 1994 - Elsevier
The anti-ischemic effects of a new, selective and potent cyclic 3′,5′-guanosine
monophosphate-specific phosphodiesterase (phosphodiesterase type V) inhibitor, sodium 1-[6-chloro-…

Beneficial effects of long-term enalapril treatment and low-salt intake on survival rate of Dahl salt-sensitive rats with established hypertension

K Kodama, H Adachi, J Sonoda - Journal of Pharmacology and Experimental …, 1997 - ASPET
We investigated the effects of long-term treatment with the angiotensin-converting enzyme
inhibitor enalapril and low-salt intake on the survival rate of Dahl salt-sensitive rats fed a high-…

Vasorelaxant effect of a phosphodiesterase 3 inhibitor, olprinone, on isolated human radial artery

H Adachi, S Kamata, K Kodama, T Nagakura - European Journal of …, 2000 - Elsevier
The radial artery is currently used as a viable arterial conduit for myocardial revascularization.
The aims of this study were to identify phosphodiesterase 3 isoenzyme in the human …