Reactive oxygen species (ROS) play a key role in promoting mitochondrial cytochrome c
release and induction of apoptosis. ROS induce dissociation of cytochrome c from cardiolipin …

Oxidative stress and mitochondrial oxidative damage have been implicated in aging and
many common diseases. Mitochondria are a primary source of reactive oxygen species (ROS) …

A large body of evidence suggests that mitochondrial dysfunction and oxidative damage
play a role in the pathogenesis of Parkinson's disease (PD). A number of antioxidants have …

Oligopeptides are generally thought to have poor permeability across biological membranes.
Recent studies, however, suggest significant distribution of [Dmt 1 ]DALDA (Dmt-d-Arg-Phe-…

Introduction A novel amyloid β (Aβ) synthetic peptide vaccine (UB-311) has been evaluated
in a first-in-human trial with patients of mild-to-moderate Alzheimer's disease. We describe …

Apoptotic cell death is a defined pathway for islet cell demise, and mitochondrial dysfunction
contributes to islet cell apoptosis. The hypothesis that the novel peptide d-Arg-2′, 6′-…

Fluorescent labels are commonly used to investigate the mechanisms of cellular uptake and
intracellular distribution of cell‐penetrating peptides. However, labels such as fluorescein …

We have previously reported that bone marrow B cell precursors from thymic-deprived nude
and old mice express less recombination-activating gene-1 (RAG-1) mRNA than they do in …

The number of bone marrow pre-B cells is significantly lower in 18- than in 2-month-old
BALB/c mice. The percentage of apoptotic pre-B cells, freshly isolated or cultured, from 18-month-…

The increase in autoantibodies with age of both experimental animals and humans has
been thought to reflect a shift in the antibody repertoire from foreign to self antigens. In mice, …