The “toll” of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia
LR Watkins, MR Hutchinson, KC Rice… - Trends in pharmacological …, 2009 - cell.com
Glial activation participates in the mediation of pain including neuropathic pain, due to
release of neuroexcitatory, proinflammatory products. Glial activation is now known to occur in …
release of neuroexcitatory, proinflammatory products. Glial activation is now known to occur in …
Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia
Vastly stimulated by the discovery of opioid receptors in the early 1970s, preclinical and
clinical research was directed at the study of stereoselective neuronal actions of opioids, …
clinical research was directed at the study of stereoselective neuronal actions of opioids, …
Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward
…, ST Bland, KW Johnson, KC Rice… - The scientific world …, 2007 - hindawi.com
This review will introduce the concept of toll-like receptor (TLR)–mediated glial activation as
central to all of the following: neuropathic pain, compromised acute opioid analgesia, and …
central to all of the following: neuropathic pain, compromised acute opioid analgesia, and …
Cannabinoid receptor localization in brain.
…, LS Melvin, BR De Costa, KC Rice - Proceedings of the …, 1990 - National Acad Sciences
[3H]CP 55,940, a radiolabeled synthetic cannabinoid, which is 10-100 times more potent in
vivo than delta 9-tetrahydrocannabinol, was used to characterize and localize a specific …
vivo than delta 9-tetrahydrocannabinol, was used to characterize and localize a specific …
Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study
…, LS Melvin, BR de Costa, KC Rice - Journal of …, 1991 - Soc Neuroscience
A potent, synthetic cannabinoid was radiolabeled and used to characterize and precisely
localize cannabinoid receptors in slide- mounted sections of rat brain and pituitary. Assay …
localize cannabinoid receptors in slide- mounted sections of rat brain and pituitary. Assay …
Amphetamine‐type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin
…, MH Baumann, CM Dersch, DV Romero, KC Rice… - Synapse, 2001 - Wiley Online Library
A large body of evidence supports the hypothesis that mesolimbic dopamine (DA) mediates,
in animal models, the reinforcing effects of central nervous system stimulants such as …
in animal models, the reinforcing effects of central nervous system stimulants such as …
Salvinorin A: a potent naturally occurring nonnitrogenous κ opioid selective agonist
…, R Westkaemper, D Siebert, KC Rice… - Proceedings of the …, 2002 - National Acad Sciences
Salvia divinorum, whose main active ingredient is the neoclerodane diterpene Salvinorin A,
is a hallucinogenic plant in the mint family that has been used in traditional spiritual …
is a hallucinogenic plant in the mint family that has been used in traditional spiritual …
Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: relation to hypercortisolism and corticotropin-releasing …
…, MD DeBellis, KC Rice… - Proceedings of the …, 2000 - National Acad Sciences
Both stress-system activation and melancholic depression are characterized by fear,
constricted affect, stereotyped thinking, and similar changes in autonomic and neuroendocrine …
constricted affect, stereotyped thinking, and similar changes in autonomic and neuroendocrine …
[PDF][PDF] Cannabinoid structure-activity relationships: correlation of receptor binding and in vivo activities.
DR Compton, KC Rice, BR De Costa… - … of Pharmacology and …, 1993 - researchgate.net
Although a receptor exists for cannabinoid drugs, it is uncertain which pharmacological
actions this receptor mediates. This structure-activity relationship investigation was initiated to …
actions this receptor mediates. This structure-activity relationship investigation was initiated to …
Evidence that opioids may have toll-like receptor 4 and MD-2 effects
…, LA Leinwand, SF Maier, H Yin, KC Rice… - Brain, behavior, and …, 2010 - Elsevier
Opioid-induced proinflammatory glial activation modulates wide-ranging aspects of opioid
pharmacology including: opposition of acute and chronic opioid analgesia, opioid analgesic …
pharmacology including: opposition of acute and chronic opioid analgesia, opioid analgesic …