A possible mechanism of eighteen patient deaths caused by interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs
H Okuda, K Ogura, A Kato, H Takubo… - Journal of Pharmacology …, 1998 - ASPET
A toxicokinetic study was performed using rats to investigate the possible mechanism of 18
acute deaths in Japanese patients with cancer and herpes zoster by interactions of the new …
acute deaths in Japanese patients with cancer and herpes zoster by interactions of the new …
Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR
H Lu, S Choudhuri, K Ogura, IL Csanaky… - Toxicological …, 2008 - academic.oup.com
The liver-specific importer organic anion transporting polypeptide 1b2 (Oatp1b2, Slco1b2,
also known as Oatp4 and Lst-1) and its human orthologs OATP1B1/1B3 transport a large …
also known as Oatp4 and Lst-1) and its human orthologs OATP1B1/1B3 transport a large …
[PDF][PDF] Organic anion–transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2‐null mice
The organic anion–transporting polypeptide 1b family (Oatp1b2 in rodents and OATP1B1/1B3
in humans) is liver‐specific and transports various chemicals into the liver. However, the …
in humans) is liver‐specific and transports various chemicals into the liver. However, the …
Lethal drug interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs
H Okuda, T Nishiyama, K Ogura, S Nagayama… - Drug metabolism and …, 1997 - ASPET
Rats were orally co-administered sorivudine (SRV: 1-β-d-arabinofuranosyl-(E)-5-(2-bromovinyl)uracil),
a new oral antiviral drug for herpes zoster, with the oral anticancer drug tegafur (…
a new oral antiviral drug for herpes zoster, with the oral anticancer drug tegafur (…
Sulfation of environmental estrogens by cytosolic human sulfotransferases
T Nishiyama, K Ogura, H Nakano, T Kaku… - Drug metabolism and …, 2002 - Elsevier
It is known that in humans taking soy food, the phytoestrogens, daidzein (DZ) and genistein (GS),
exist as sulfates and glucuronides in the plasma and are excreted as conjugates in …
exist as sulfates and glucuronides in the plasma and are excreted as conjugates in …
Reverse geometrical selectivity in glucuronidation and sulfation of cis-and trans-4-hydroxytamoxifens by human liver UDP-glucuronosyltransferases and …
T Nishiyama, K Ogura, H Nakano, T Ohnuma… - Biochemical …, 2002 - Elsevier
The phenolic active metabolites, cis-4-hydroxytamoxifen (cis-HO-TAM) and trans-4-hydroxytamoxifen
(trans-HO-TAM), of the antibreast cancer drug, trans-tamoxifen (TAM), were …
(trans-HO-TAM), of the antibreast cancer drug, trans-tamoxifen (TAM), were …
Induction of rat organic anion transporting polypeptide 2 by pregnenolone-16α-carbonitrile is via interaction with pregnane X receptor
GL Guo, J Staudinger, K Ogura, CD Klaassen - Molecular pharmacology, 2002 - ASPET
The rat organic anion transporting polypeptide 2 (oatp2; Slc21a5) is a liver transporter that
mediates the uptake of a variety of structurally diverse compounds, and has a high affinity for …
mediates the uptake of a variety of structurally diverse compounds, and has a high affinity for …
Regioselective monosulfation and disulfation of the phytoestrogens daidzein and genistein by human liver sulfotransferases
H Nakano, K Ogura, E Takahashi, T Harada… - Drug metabolism and …, 2004 - jstage.jst.go.jp
Regioselective sulfation of the phytoestrogens daidzein (DZ, 7, 4?-dihydroxyiso‰ avone)
and genistein (GS, 5, 7, 4?-trihydroxyiso‰ avone) was investigated using human liver cytosol …
and genistein (GS, 5, 7, 4?-trihydroxyiso‰ avone) was investigated using human liver cytosol …
Activation of the Nrf2/ARE pathway via S-alkylation of cysteine 151 in the chemopreventive agent-sensor Keap1 protein by falcarindiol, a conjugated diacetylene …
…, S Nakayama, E Anan, T Nishiyama, K Ogura… - Toxicology and applied …, 2010 - Elsevier
Under basal conditions, the interaction of the cytosolic protein Kelch-like ECH-associated
protein 1 (Keap1) with the transcription factor nuclear factor-E2-related factor 2 (Nrf2) results in …
protein 1 (Keap1) with the transcription factor nuclear factor-E2-related factor 2 (Nrf2) results in …
Enhanced sensitivity of A549 cells to the cytotoxic action of anticancer drugs via suppression of Nrf2 by procyanidins from Cinnamomi Cortex extract
…, A Itoi, A Kawana, T Nishiyama, K Ogura… - Biochemical and …, 2011 - Elsevier
Nuclear factor-E2-related factor 2 (Nrf2) is an important cytoprotective transcription factor
because Nrf2-regulated enzymes play a key role in antioxidant and detoxification processes. …
because Nrf2-regulated enzymes play a key role in antioxidant and detoxification processes. …