RhoA/Rho-kinase pathway plays an important role in many pathological conditions. RhoA
participates in the regulation of smooth muscle tone and activates many downstream kinases. …

… Nunes, Kenia Pedrosa; Labazi, Hicham; Webb, R. Clinton … This work was supported by
NIH and Dr Nunes is supported by AHA. … Nunes KP, Rigsby CS, Webb RC. RhoA/Rho-kinase …

Hypertension is a multifactorial disease. Although a number of different underlying mechanisms
have been learned from the various experimental models of the disease, hypertension …

The venom of the spider Phoneutria nigriventer contains several toxins that have bioactivity
in mammals and insects. Accidents involving humans are characterized by various …

The immune system plays a prominent role in the initiation and maintenance of hypertension.
The innate immune system, via toll‐like receptors (TLRs), identifies distinct signatures of …

A diagnostic of hypertension increases the risk of erectile dysfunction (ED); likewise, ED can
be an early sign of hypertension. In both cases, there is evidence that endothelial …

Emerging evidence indicates that HSP70 represents a key mechanism in the pathophysiology
of β-cell dysfunction, insulin resistance, and various diabetic complications, including …

While Rho-signalling controlling vascular contraction is a canonical mechanism, with the
modern approaches used in research, we are advancing our understanding and details into …

The venom of Phoneutria nigriventer spider has been extensively studied. It is highly
neurotoxic, with clinical manifestations occurring a few minutes after the bite, mainly in children. …

Purpose : We designed a peptide, PnPP-19, comprising the potential active core of the
Phoneutria nigriventer native toxin PnTx2-6. We investigated its role on erectile function, and its …