25-Hydroxyvitamin D3 1α-Hydroxylase and Vitamin D Synthesis
K Takeyama, S Kitanaka, T Sato, M Kobori… - Science, 1997 - science.org
Renal 25–hydroxyvitamin D 3 1α-hydroxylase [1α(OH)ase] catalyzes metabolic activation of
25–hydroxyvitamin D 3 into 1α,25–dihydroxyvitamin D 3 [1α,25(OH) 2 D 3 ], an active form of …
25–hydroxyvitamin D 3 into 1α,25–dihydroxyvitamin D 3 [1α,25(OH) 2 D 3 ], an active form of …
Modulation of oestrogen receptor signalling by association with the activated dioxin receptor
F Ohtake, K Takeyama, T Matsumoto, H Kitagawa… - Nature, 2003 - nature.com
Environmental contaminants affect a wide variety of biological events in many species. Dioxins
are typical environmental contaminants that exert adverse oestrogen-related effects 1 . …
are typical environmental contaminants that exert adverse oestrogen-related effects 1 . …
DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs
…, C Foulds, S Takezawa, H Kitagawa, K Takeyama… - Nature cell …, 2007 - nature.com
MicroRNAs (miRNAs) control cell proliferation, differentiation and fate through modulation of
gene expression by partially base-pairing with target mRNA sequences 1 , 2 , 3 , 4 , 5 , 6 . …
gene expression by partially base-pairing with target mRNA sequences 1 , 2 , 3 , 4 , 5 , 6 . …
A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-γ transactivation
…, S Kobayashi, M Igarashi, MY Youn, K Takeyama… - Nature cell …, 2007 - nature.com
Histone modifications induced by activated signalling cascades are crucial to cell-lineage
decisions. Osteoblast and adipocyte differentiation from common mesenchymal stem cells is …
decisions. Osteoblast and adipocyte differentiation from common mesenchymal stem cells is …
Androgen receptor function in folliculogenesis and its clinical implication in premature ovarian failure
…, R Matsuyama, H Shiina, T Sato, K Takeyama… - Trends in Endocrinology …, 2007 - cell.com
The action of estrogen in the female reproductive organs is well known in terms of the
expression pattern and gene regulation of the estrogen receptor (ER). The significance of ERs in …
expression pattern and gene regulation of the estrogen receptor (ER). The significance of ERs in …
[HTML][HTML] Inactivating Mutations in the 25-Hydroxyvitamin D3 1α-Hydroxylase Gene in Patients with Pseudovitamin D–Deficiency Rickets
S Kitanaka, K Takeyama, A Murayama… - … England Journal of …, 1998 - Mass Medical Soc
Background Pseudovitamin D–deficiency rickets is characterized by the early onset of rickets
with hypocalcemia and is thought to be caused by a deficit in renal 25-hydroxyvitamin D 3 …
with hypocalcemia and is thought to be caused by a deficit in renal 25-hydroxyvitamin D 3 …
[PDF][PDF] A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing
…, A Krasnov, SG Georgieva, R Schüle, KI Takeyama… - Molecular cell, 2008 - cell.com
Transcriptional activators, several different coactivators, and general transcription factors are
necessary to access specific loci in the dense chromatin structure to allow precise initiation …
necessary to access specific loci in the dense chromatin structure to allow precise initiation …
Molecular mechanism of a cross‐talk between oestrogen and growth factor signalling pathways
…, M Watanabe, Y Kobayashi, K Takeyama… - Genes to …, 2000 - Wiley Online Library
Oestrogen (E 2 ) plays significant roles in variety of biological events such as the development
and maintenance of female reproductive organs, bone and lipid metabolisms. More …
and maintenance of female reproductive organs, bone and lipid metabolisms. More …
Positive and Negative Regulations of the Renal 25-Hydroxyvitamin D3 1α-Hydroxylase Gene by Parathyroid Hormone, Calcitonin, and 1α,25(OH)2D3 in Intact …
A Murayama, K Takeyama, S Kitanaka, Y Kodera… - …, 1999 - academic.oup.com
Reflecting the prime role of 1α,25(OH) 2 D 3 in calcium homeostasis, the activity of 25-hydroxyvitamin
D 3 1α-hydroxylase, a key enzyme for 1α,25(OH) 2 D 3 biosynthesis, is tightly …
D 3 1α-hydroxylase, a key enzyme for 1α,25(OH) 2 D 3 biosynthesis, is tightly …
The vitamin D3 1alpha-hydroxylase gene and its regulation by active vitamin D3
K Takeyama, S Kato - Bioscience, biotechnology, and biochemistry, 2011 - jstage.jst.go.jp
Vitamin D has a pivotal role in a many biological processes, including the maintenance of
calcium homeostasis, cell differentiation and proliferation. Most of these actions are mediated …
calcium homeostasis, cell differentiation and proliferation. Most of these actions are mediated …