Membrane permeability and P-glycoprotein (Pgp) can be limiting factors for blood-brain barrier
penetration. The objectives of this study were to determine whether there are differences …

Statins are the preferred class of drugs for treating patients with atherosclerosis and related
coronary heart disease. Treatment with statins leads to significant low-density lipoprotein …

Purpose To measure fasted and fed gastric pH and gastric residence time (GRT) in
Cynomolgus monkeys using Bravo® radiotelemetry capsules. Methods Continuous pH …

This study was conducted to compare the ability of two potential microdialysis perfusates to
enhance the recovery of SB‐265123, a lipophilic, highly protein‐bound compound, both in …

Blood–brain barrier (BBB) transport of essential polar substrates is mediated by specific,
carrier-mediated transport proteins. The BBB transport mechanisms for polar compounds with …

Pharmacokinetic/pharmacodynamic simulations were performed to assess the feasibility of
central nervous system (CNS) drug delivery via endogenous transporters resident at the …

Aminoguanidine has potential pharmacologic utility for diabetes and nitric oxide — mediated
inflammation. Because aminoguanidine is positively charged at physiologic pH (pK a ∼10)…

To further characterize the time course of gastric pH with respect to meals and gastric
residence times (GRTs) in dogs, continuous pH measurements were recorded with Bravo® …

The purpose of this study was to measure the in vivo brain distribution of antihistamines and
assess the influence of in vitro permeability, P-glycoprotein (Pgp) efflux, and plasma protein …

… The two part study design permitted a shortened recruitment period and ability to
terminate progression only 7 months after study start; thereby saving significant time (~5-7 …