Inhibition of allergic dermal inflammation by the novel imidazopyridazine derivative TAK-427 in a guinea pig experimental model of eczema

S Fukuda, K Midoro, T Kamei, M Gyoten… - … of Pharmacology and …, 2002 - ASPET
Antigen challenge by patch ovalbumin emulsion induced an eczema-like skin lesion in
epicutaneously sensitized guinea pigs. Diseased skin sites were macroscopically characterized …

Effects of TAK-427 on acute nasal symptoms and nasal obstruction in guinea pig model of experimental allergic rhinitis

S Fukuda, K Midoro, M Gyoten, Y Kawano… - European journal of …, 2003 - Elsevier
TAK-427 {2-[6-[[3-[4-(diphenylmethoxy)piperidino]propyl]amino]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionic
acid dihydrate} is a novel anti-allergic agent that has both histamine H 1 -…

Immunopathology of Chronic Progressive Hepatitis in Nude Mice Infected with Low‐Virulent Mouse Hepatitis Virus

K Midoro, K Nakanaga, S Kyuwa… - Microbiology and …, 1989 - Wiley Online Library
Progressive hepatitis in athymic nude (nu/nu) mice due to a low‐virulent mouse hepatitis
virus, MHV‐2 cc, was examined for involvement of immunocytes and serum antibodies. At 3 to …

Antitumor Effects of 5′‐Deoxy‐S‐fluorouridine in Combination with Recombinant Human Interleukin 2 on Murine Colon Carcinoma 26

K Midoro, K Gotoh, T Houkan… - Japanese journal of …, 1997 - Wiley Online Library
The antitumor activity of rccombinant human interleukin 2 (rIL‐2) in combination with 5′‐deoxy‐5‐fluorouridine
(doxifluridine; 5′‐DFUR) against murine colon carcinoma 26 (Colon 26…

Two cases of canine insulinoma.

美土路活男, 中山裕之, 岡田信彦, 小野憲一郎… - 日本獸醫學雜誌 (The …, 1987 - jlc.jst.go.jp
Only a few canine cases of insulin—secreting neoplasm arising from pancreatic islets and
causing a hypoglycemia leading to neurologic disturbance have been reported in several …

Systemic proliferative vasculitis and glomerulonephritis in ICR-nude mice infected with mouse hepatitis virus.

柳澤利彦, 杉本次郎, 美 [ド] 路活男… - 日本獸醫學雜誌 (The …, 1986 - jlc.jst.go.jp
ICR-nude mice inoculated intraperitoneally with MHV-NuU, showed progressive proteinuria
and had virus in the kidney at 2 to 5 weeks postinoculation. In the renal glomeruli, …

Electron microscopic observations on sporulation of Tyzzer's organism," Bacillus piliformis".

岡田信彦, 美 [ド] 路活男, 藤原公策 - 日本獸醫學雜誌 (The Japanese …, 1986 - jlc.jst.go.jp
The process of spore formation was observed by electron microscopy with three strains of
Tyzzer's Organisms, "Bacillus piliformis" having a high frequency of sporulation. The …

Synthesis of eosinophil infiltration inhibitors with antihistaminic activity

M Gyoten, H Nagaya, S Fukuda, Y Ashida… - Chemical and …, 2003 - jstage.jst.go.jp
A series of [1, 2, 4] triazolo [1, 5-b] pyridazines (5) and imidazo [1, 2-b] pyridazines (6) having
cyclic amines was synthesized and evaluated for antihistaminic activity and inhibitory effect …

An equine case of granular cell tumor with chondroplasia.

井上智, 岡田信彦, 美土路活男, 中山裕之… - 日本獸醫學雜誌 (The …, 1987 - jlc.jst.go.jp
The incidence of primary pulmonary tumors is very low in horses and only a few cases of
granular cell tumor have been reported [9, 12, 14, 16]. This note is to describe pathologic …

Fatal herpesvirus infection in a litter of puppies.

柳澤利彦, 畔高政行, 美土路活男, 高橋令治… - 日本獸醫學雜誌 (The …, 1987 - jlc.jst.go.jp
Fatal canine herpesvirus (CHV) infection in neonatal puppies characterized by hemorrhage
and necrosis in various tissues was first described by Carmichael et al.[1], and the …