User profiles for Kathryn Braden
Kathryn BradenWashington University in St. Louis Verified email at wustl.edu Cited by 184 |
Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain
The development of chemotherapy-induced painful peripheral neuropathy is a major dose-limiting
side effect of many chemotherapeutics, including bortezomib, but the mechanisms …
side effect of many chemotherapeutics, including bortezomib, but the mechanisms …
Sexually dimorphic therapeutic response in bortezomib-induced neuropathic pain reveals altered pain physiology in female rodents
K Stockstill, C Wahlman, K Braden, Z Chen, GL Yosten… - Pain, 2020 - journals.lww.com
Chemotherapy-induced neuropathic pain (CINP) in both sexes compromises many current
chemotherapeutics and lacks an FDA-approved therapy. We recently identified the …
chemotherapeutics and lacks an FDA-approved therapy. We recently identified the …
GPR183-oxysterol axis in spinal cord contributes to neuropathic pain
K Braden, LA Giancotti, Z Chen, C DeLeon… - … of Pharmacology and …, 2020 - ASPET
Neuropathic pain is a debilitating public health concern for which novel non-narcotic therapeutic
targets are desperately needed. Using unbiased transcriptomic screening of the dorsal …
targets are desperately needed. Using unbiased transcriptomic screening of the dorsal …
[HTML][HTML] Small molecule targeting NaV1. 7 via inhibition of the CRMP2-Ubc9 interaction reduces and prevents pain chronification in a mouse model of oxaliplatin …
Abstract Treatment with anti-neoplastic agents can lead to the development of chemotherapy
induced peripheral neuropathy (CIPN), which is long lasting and often refractory to …
induced peripheral neuropathy (CIPN), which is long lasting and often refractory to …
Activation of GPR183 by 7α, 25-dihydroxycholesterol induces behavioral hypersensitivity through mitogen-activated protein kinase and nuclear factor-κB
Emerging evidence implicates the G-protein coupled receptor (GPCR) GPR183 in the
development of neuropathic pain. Further investigation of the signaling pathways downstream of …
development of neuropathic pain. Further investigation of the signaling pathways downstream of …
Kappa opioid receptors as modulators of novelty processing
A long-standing notion is that kappa opioid receptors (KOPR) are part of negative valence
brain systems that contribute to anhedonia and aversive motivated behaviors. Overactivation …
brain systems that contribute to anhedonia and aversive motivated behaviors. Overactivation …
[HTML][HTML] Sphingosine-1-phosphate receptor subtype 1 activation in the central nervous system contributes to morphine withdrawal in rodents
TM Doyle, MR Hutchinson, K Braden, K Janes… - Journal of …, 2020 - Springer
Opioid therapies for chronic pain are undermined by many adverse side effects that reduce
their efficacy and lead to dependence, abuse, reduced quality of life, and even death. We …
their efficacy and lead to dependence, abuse, reduced quality of life, and even death. We …
The Role of Nitric Oxide In 7α, 25-Dihydroxycholesterol-Induced Peripheral Sensitization
K Oberkrom, K Braden, Z Chen, LA Giancotti… - The Journal of …, 2024 - Elsevier
Neuropathic pain afflicts millions of people worldwide. Current pharmacological therapies for
neuropathic pain have multiple side effects and limited efficacy; therefore, novel treatment …
neuropathic pain have multiple side effects and limited efficacy; therefore, novel treatment …
Activation of GPR183 by 7α, 25-dihydroxycholesterol induces behavioral hypersensitivity through MAPK and NF-κB
K Braden, M Campolo, Y Li, Z Chen, TM Doyle… - … of Pharmacology and …, 2022 - ASPET
Emerging evidence implicates the G-protein coupled receptor (GPCR), GPR183 in the
development of neuropathic pain. Continued investigation of the signaling pathways downstream …
development of neuropathic pain. Continued investigation of the signaling pathways downstream …
[HTML][HTML] Novel non-opioid based therapeutics for chronic neuropathic pain
Chronic neuropathic pain is currently a major health issue in US complicated by the lack of
non-opioid analgesic alternatives. Our investigations led to the discovery of major signaling …
non-opioid analgesic alternatives. Our investigations led to the discovery of major signaling …