[HTML][HTML] Combination of high-fat/high-fructose diet and low-dose streptozotocin to model long-term type-2 diabetes complications
…, G Roussy, F Lizotte, A Kessai, K Kirby, K Belleville… - Scientific Reports, 2018 - nature.com
The epidemic of type 2 diabetes mellitus (T2DM) is fueled by added fructose consumption.
Here, we thus combined high-fat/high-fructose diet, with multiple low-dose injections of …
Here, we thus combined high-fat/high-fructose diet, with multiple low-dose injections of …
[HTML][HTML] Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties
…, A Murza, P Tétreault, K Belleville… - The Journal of …, 2014 - Am Soc Clin Investig
Neurotensin (NT) has emerged as an important modulator of nociceptive transmission and
exerts its biological effects through interactions with 2 distinct GPCRs, NTS1 and NTS2. NT …
exerts its biological effects through interactions with 2 distinct GPCRs, NTS1 and NTS2. NT …
Stability and degradation patterns of chemically modified analogs of apelin‐13 in plasma and cerebrospinal fluid
Apelin is the endogenous ligand of APJ, which belongs to the superfamily of G protein‐coupled
receptors. In recent years, the apelin/APJ system has been detected in many tissues and …
receptors. In recent years, the apelin/APJ system has been detected in many tissues and …
[HTML][HTML] Behavioral, medical imaging and histopathological features of a new rat model of bone cancer pain
L Doré-Savard, V Otis, K Belleville, M Lemire… - PLoS …, 2010 - journals.plos.org
Pre-clinical bone cancer pain models mimicking the human condition are required to
respond to clinical realities. Breast or prostate cancer patients coping with bone metastases …
respond to clinical realities. Breast or prostate cancer patients coping with bone metastases …
Evidence for a role of NTS2 receptors in the modulation of tonic pain sensitivity
…, S Baudisson, F Ezzoubaa, K Belleville… - Molecular …, 2009 - journals.sagepub.com
Background Central neurotensin (NT) administration results in a naloxone-insensitive
antinociceptive response in animal models of acute and persistent pain. Both NTS1 and NTS2 …
antinociceptive response in animal models of acute and persistent pain. Both NTS1 and NTS2 …
Spinal NTS1 receptors regulate nociceptive signaling in a rat formalin tonic pain model
…, L Doré‐Savard, K Belleville… - Journal of …, 2008 - Wiley Online Library
Central administration of the neuropeptide neurotensin (NT) was shown to induce
antinociceptive responses both spinally and supraspinally. Although NTS2 receptors play an …
antinociceptive responses both spinally and supraspinally. Although NTS2 receptors play an …
Epithelial BMP signaling is required for proper specification of epithelial cell lineages and gastric endocrine cells
…, E Roy, K Belleville… - American Journal …, 2011 - journals.physiology.org
Bone morphogenetic protein (BMP) signaling within the gastrointestinal tract is complex.
BMP ligands and their receptors are expressed in both epithelial and mesenchymal …
BMP ligands and their receptors are expressed in both epithelial and mesenchymal …
Spinal NTS2 receptor activation reverses signs of neuropathic pain
Management of painful peripheral neuropathies remains challenging, since patients with
chronic pain respond poorly to the available pharmacopeia. In recent years, the G‐protein‐…
chronic pain respond poorly to the available pharmacopeia. In recent years, the G‐protein‐…
A systematic exploration of macrocyclization in apelin-13: impact on binding, signaling, stability, and cardiovascular effects
…, D Coquerel, J Cote, K Belleville… - Journal of medicinal …, 2018 - ACS Publications
The apelin receptor generates increasing interest as a potential target across several
cardiovascular indications. However, the short half-life of its cognate ligands, the apelin peptides, …
cardiovascular indications. However, the short half-life of its cognate ligands, the apelin peptides, …
Ghrelin Inhibition Restores Glucose Homeostasis in Hepatocyte Nuclear Factor-1α (MODY3)–Deficient Mice
Hepatocyte nuclear factor-1α (HNF1α) is a transcription factor expressed in tissues of endoderm
origin. Mutations in HNF1A are associated with maturity-onset diabetes of the young 3 (…
origin. Mutations in HNF1A are associated with maturity-onset diabetes of the young 3 (…