[HTML][HTML] Combination of high-fat/high-fructose diet and low-dose streptozotocin to model long-term type-2 diabetes complications

…, G Roussy, F Lizotte, A Kessai, K Kirby, K Belleville… - Scientific Reports, 2018 - nature.com
The epidemic of type 2 diabetes mellitus (T2DM) is fueled by added fructose consumption.
Here, we thus combined high-fat/high-fructose diet, with multiple low-dose injections of …

[HTML][HTML] Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties

…, A Murza, P Tétreault, K Belleville… - The Journal of …, 2014 - Am Soc Clin Investig
Neurotensin (NT) has emerged as an important modulator of nociceptive transmission and
exerts its biological effects through interactions with 2 distinct GPCRs, NTS1 and NTS2. NT …

Stability and degradation patterns of chemically modified analogs of apelin‐13 in plasma and cerebrospinal fluid

A Murza, K Belleville, JM Longpré, P Sarret… - Peptide …, 2014 - Wiley Online Library
Apelin is the endogenous ligand of APJ, which belongs to the superfamily of G protein‐coupled
receptors. In recent years, the apelin/APJ system has been detected in many tissues and …

[HTML][HTML] Behavioral, medical imaging and histopathological features of a new rat model of bone cancer pain

L Doré-Savard, V Otis, K Belleville, M Lemire… - PLoS …, 2010 - journals.plos.org
Pre-clinical bone cancer pain models mimicking the human condition are required to
respond to clinical realities. Breast or prostate cancer patients coping with bone metastases …

Evidence for a role of NTS2 receptors in the modulation of tonic pain sensitivity

…, S Baudisson, F Ezzoubaa, K Belleville… - Molecular …, 2009 - journals.sagepub.com
Background Central neurotensin (NT) administration results in a naloxone-insensitive
antinociceptive response in animal models of acute and persistent pain. Both NTS1 and NTS2 …

Spinal NTS1 receptors regulate nociceptive signaling in a rat formalin tonic pain model

…, L Doré‐Savard, K Belleville… - Journal of …, 2008 - Wiley Online Library
Central administration of the neuropeptide neurotensin (NT) was shown to induce
antinociceptive responses both spinally and supraspinally. Although NTS2 receptors play an …

Epithelial BMP signaling is required for proper specification of epithelial cell lineages and gastric endocrine cells

…, E Roy, K Belleville… - American Journal …, 2011 - journals.physiology.org
Bone morphogenetic protein (BMP) signaling within the gastrointestinal tract is complex.
BMP ligands and their receptors are expressed in both epithelial and mesenchymal …

Spinal NTS2 receptor activation reverses signs of neuropathic pain

P Tétreault, N Beaudet, A Perron, K Belleville… - The FASEB …, 2013 - Wiley Online Library
Management of painful peripheral neuropathies remains challenging, since patients with
chronic pain respond poorly to the available pharmacopeia. In recent years, the G‐protein‐…

A systematic exploration of macrocyclization in apelin-13: impact on binding, signaling, stability, and cardiovascular effects

…, D Coquerel, J Cote, K Belleville… - Journal of medicinal …, 2018 - ACS Publications
The apelin receptor generates increasing interest as a potential target across several
cardiovascular indications. However, the short half-life of its cognate ligands, the apelin peptides, …

Ghrelin Inhibition Restores Glucose Homeostasis in Hepatocyte Nuclear Factor-1α (MODY3)–Deficient Mice

F Brial, CR Lussier, K Belleville, P Sarret… - Diabetes, 2015 - Am Diabetes Assoc
Hepatocyte nuclear factor-1α (HNF1α) is a transcription factor expressed in tissues of endoderm
origin. Mutations in HNF1A are associated with maturity-onset diabetes of the young 3 (…