Blood–brain barrier transport of morphine in patients with severe brain trauma

P Ederoth, K Tunblad, R Bouw… - British journal of …, 2004 - Wiley Online Library
Aims In experimental studies, morphine pharmacokinetics is different in the brain compared
with other tissues due to the properties of the blood–brain barrier, including action of efflux …

Blood‐brain barrier transport and brain distribution of morphine‐6‐glucuronide in relation to the antinociceptive effect in rats–pharmacokinetic/pharmacodynamic …

MR Bouw, R Xie, K Tunblad… - British journal of …, 2001 - Wiley Online Library
The objective of this study was to investigate the contribution of the blood‐brain barrier (BBB)
transport to the delay in antinociceptive effect of morphine‐6‐glucuronide (M6G), and to …

Morphine blood-brain barrier transport is influenced by probenecid co-administration

K Tunblad, EN Jonsson… - Pharmaceutical …, 2003 - Springer
Purpose. The objective of this study was to investigate the possible influence of probenecid
on morphine transport across the blood-brain barrier (BBB) in rats. Methods. Microdialysis …

[HTML][HTML] The selective cathepsin K inhibitor MIV-711 attenuates joint pathology in experimental animal models of osteoarthritis

E Lindström, B Rizoska, K Tunblad, C Edenius… - Journal of translational …, 2018 - Springer
Background MIV-711 is a highly potent and selective cathepsin K inhibitor. The current article
summarizes the therapeutic effects of MIV-711 on joint pathology in rabbits subjected to …

An integrated model for the analysis of pharmacokinetic data from microdialysis experiments

K Tunblad, M Hammarlund-Udenaes… - Pharmaceutical …, 2004 - Springer
Purpose. To develop an integrated model for microdialysis data that incorporates all data
including the recovery measurements in one model, and to compare this model to a previous …

Selective cathepsin S inhibition with MIV-247 attenuates mechanical allodynia and enhances the antiallodynic effects of gabapentin and pregabalin in a mouse model …

E Hewitt, T Pitcher, B Rizoska, K Tunblad… - … of Pharmacology and …, 2016 - ASPET
Cathepsin S inhibitors attenuate mechanical allodynia in preclinical neuropathic pain models.
The current study evaluated the effects when combining the selective cathepsin S inhibitor …

[HTML][HTML] Analgesic effects of the cathepsin K inhibitor L-006235 in the monosodium iodoacetate model of osteoarthritis pain

…, PRW Gowler, JJ Burston, B Rizoska, K Tunblad… - Pain …, 2018 - journals.lww.com
Methods: Effects of preventative (30 and 100 mg/kg) and therapeutic (100 mg/kg) oral dosing
with L-006235 on weight-bearing asymmetry, hind paw withdrawal thresholds, cartilage …

Altered brain exposure of morphine in experimental meningitis studied with microdialysis

K Tunblad, P Ederoth, A Gärdenfors… - Acta …, 2004 - Wiley Online Library
Background: During pathologic conditions such as meningitis and traumatic brain injury the
function of the blood–brain barrier (BBB) is disturbed. In the present study we examined the …

Influence of probenecid on the delivery of morphine-6-glucuronide to the brain

K Tunblad, M Hammarlund-Udenaes… - European journal of …, 2005 - Elsevier
The objective was to evaluate the influence of probenecid on the blood–brain barrier (BBB)
transport of morphine-6-glucuronide (M6G). Microdialysis probes were placed in the striatum …

The use of clinical irrelevance criteria in covariate model building with application to dofetilide pharmacokinetic data

K Tunblad, L Lindbom, L McFadyen… - … of pharmacokinetics and …, 2008 - Springer
To characterise the pharmacokinetics of dofetilide in patients and to identify clinically relevant
parameter–covariate relationships. To investigate three different modelling strategies in …