Airway remodeling in subjects with severe asthma with or without chronic persistent airflow obstruction

M Kaminska, S Foley, K Maghni… - Journal of allergy and …, 2009 - Elsevier
BACKGROUND: The patterns of airway remodeling and the biomarkers that distinguish
different subtypes of severe asthma are unknown. OBJECTIVES: We sought to characterize …

1α,25-Dihydroxy-vitamin D3 stimulation of bronchial smooth muscle cells induces autocrine, contractility, and remodeling processes

Y Bossé, K Maghni, TJ Hudson - Physiological genomics, 2007 - journals.physiology.org
Genetic variants in the vitamin D receptor (VDR) gene were recently associated with asthma.
The biological mechanisms explaining this association are unknown but are likely to …

Neutrophilic airway inflammation in horses with heaves is characterized by a Th2-type cytokine profile

JP Lavoie, K Maghni, M Desnoyers, R Taha… - American journal of …, 2001 - atsjournals.org
Heaves in horses shares many similarities with human asthma, including lower airway
inflammation, reversible airway obstruction, and bronchial hyperresponsiveness. Extrinsic asthma …

Chlorine-induced injury to the airways in mice

…, DH Eidelman, Q Hamid, K Maghni - American journal of …, 2003 - atsjournals.org
Exposure to chlorine gas (Cl 2 ) causes occupational asthma that we hypothesized occurs
through the induction of airway inflammation and airway hyperresponsiveness by oxidative …

Long-term outcomes of acute irritant-induced asthma

…, K Lavoie, H Ghezzo, K Maghni - American journal of …, 2009 - atsjournals.org
Karim MaghniKarim MaghniMaghni K, Lemière C, Ghezzo H, Yuquan W, Malo JL.
Airway inflammation after cessation of exposure to agents causing occupational asthma. Am J …

IL-13 may mediate allergen-induced hyperresponsiveness independently of IL-5 or eotaxin by effects on airway smooth muscle

SY Eum, K Maghni, B Tolloczko… - … of Physiology-Lung …, 2005 - journals.physiology.org
IL-13 is a mediator of allergen-induced airway hyperresponsiveness (AHR). The aim of this
study was to evaluate whether eotaxin and IL-5 were implicated in the effects of IL-13 on …

Work-exacerbated asthma and occupational asthma: do they really differ?

…, S Chiry, H Villeneuve, P Prince, K Maghni… - Journal of allergy and …, 2013 - Elsevier
BACKGROUND: Although work-exacerbated asthma (WEA) is a prevalent condition likely to
have an important societal burden, there are limited data on this condition. OBJECTIVES: …

CCR3 expression and function in asthmatic airway smooth muscle cells

…, I Labonté, AS Gounni, K Maghni… - The Journal of …, 2005 - journals.aai.org
Asthma is characterized by an increase in airway smooth muscle mass and a decreased
distance between the smooth muscle layer and the epithelium. Furthermore, there is evidence …

Airway inflammation after cessation of exposure to agents causing occupational asthma

K Maghni, C Lemière, H Ghezzo… - American journal of …, 2004 - atsjournals.org
Subjects with occupational asthma (OA) generally present asthma symptoms and airway
hyperresponsiveness after cessation of exposure. We hypothesized that they are also left with …

The immunomodulatory actions of prostaglandin E2 on allergic airway responses in the rat

JG Martin, M Suzuki, K Maghni, R Pantano… - The Journal of …, 2002 - journals.aai.org
PGE 2 has been reported to inhibit allergen-induced airway responses in sensitized human
subjects. The aim of this study was to investigate the mechanism of anti-inflammatory actions …