Molecular and functional diversity of the expanding GABA‐A receptor gene family
…, SA Thompson, KA Wafford - Annals of the New …, 1999 - Wiley Online Library
Fast inhibitory neurotransmission in the mammalian CNS is mediated primarily by the
neurotransmitter γ‐aminobutyric acid (GABA), which, upon binding to its receptor, leads to opening …
neurotransmitter γ‐aminobutyric acid (GABA), which, upon binding to its receptor, leads to opening …
The Cys-loop superfamily of ligand-gated ion channels: the impact of receptor structure on function
CN Connolly, KA Wafford - Biochemical Society Transactions, 2004 - portlandpress.com
The Cys-loop receptors constitute an important superfamily of LGICs (ligand-gated ion channels)
comprising receptors for acetylcholine, 5-HT 3 (5-hydroxytryptamine; 5-HT 3 receptors), …
comprising receptors for acetylcholine, 5-HT 3 (5-hydroxytryptamine; 5-HT 3 receptors), …
Treating insomnia: current and investigational pharmacological approaches
B Ebert, KA Wafford, S Deacon - Pharmacology & therapeutics, 2006 - Elsevier
Chronic insomnia affects a significant proportion of young adult and elderly populations.
Treatment strategies should alleviate nighttime symptoms, the feeling of nonrestorative sleep, …
Treatment strategies should alleviate nighttime symptoms, the feeling of nonrestorative sleep, …
Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor α1 subtype
…, TW Rosahl, DS Reynolds, C Sur, KA Wafford… - Nature …, 2000 - nature.com
Inhibitory neurotransmission in the brain is largely mediated by GABA A receptors. Potentiation
of GABA receptor activation through an allosteric benzodiazepine (BZ) site produces the …
of GABA receptor activation through an allosteric benzodiazepine (BZ) site produces the …
Pharmacological characterization of a novel cell line expressing human α4β3δ GABAA receptors
…, TP Bonnert, PJ Whiting, KA Wafford - British journal of …, 2002 - Wiley Online Library
The pharmacology of the stable cell line expressing human α 4 β 3 δ GABA A receptor was
investigated using whole‐cell patch‐clamp techniques. α 4 β 3 δ receptors exhibited …
investigated using whole‐cell patch‐clamp techniques. α 4 β 3 δ receptors exhibited …
Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by α5 subunit-containing γ-aminobutyric acid type A receptors
…, JJ Lambert, TW Rosahl, KA Wafford… - Proceedings of the …, 2004 - National Acad Sciences
The principal inhibitory neurotransmitter in the mammalian brain, γ-aminobutyric acid (GABA),
is thought to regulate memory processes by activating transient inhibitory postsynaptic …
is thought to regulate memory processes by activating transient inhibitory postsynaptic …
Thymol, a constituent of thyme essential oil, is a positive allosteric modulator of human GABAA receptors and a homo‐oligomeric GABA receptor from Drosophila …
…, EM Williamson, KA Wafford… - British journal of …, 2003 - Wiley Online Library
The GABA‐modulating and GABA‐mimetic activities of the monoterpenoid thymol were
explored on human GABA A and Drosophila melanogaster homomeric RDL ac GABA receptors …
explored on human GABA A and Drosophila melanogaster homomeric RDL ac GABA receptors …
Growth factors regulate the survival and fate of cells derived from human neurospheres
…, N Wilkie, S Pollack, G Marshall, KA Wafford… - Nature …, 2001 - nature.com
Cells isolated from the embryonic, neonatal, and adult rodent central nervous system divide
in response to epidermal growth factor (EGF) and fibroblast growth factor 2 (FGF-2), while …
in response to epidermal growth factor (EGF) and fibroblast growth factor 2 (FGF-2), while …
An inverse agonist selective for α5 subunit-containing GABAA receptors enhances cognition
…, AJ Smith, F Sternfeld, FD Tattersall, KA Wafford… - … of Pharmacology and …, 2006 - ASPET
α5IA is a compound that binds with equivalent subnanomolar affinity to the benzodiazepine (BZ)
site of GABA A receptors containing an α1, α2, α3, or α5 subunit but has inverse agonist …
site of GABA A receptors containing an α1, α2, α3, or α5 subunit but has inverse agonist …
Sedation and anesthesia mediated by distinct GABAA receptor isoforms
…, R McKernan, PJ Whiting, KA Wafford - Journal of …, 2003 - Soc Neuroscience
The specific mechanisms underlying general anesthesia are primarily unknown. The intravenous
general anesthetic etomidate acts by potentiating GABA A receptors, with selectivity for …
general anesthetic etomidate acts by potentiating GABA A receptors, with selectivity for …