Background Artificial intelligence (AI) holds the promise of supporting nurses’ clinical
decision-making in complex care situations or conducting tasks that are remote from direct patient …

Non-steroidal antiinflammatory drugs (NSAIDs) are commonly used for the treatment of
inflammation, pain, and fever. Mechanistically, these compounds are believed to act via inhibition …

We provide evidence that cyclooxygenase (COX)-2-derived prostaglandins contribute to tumor
growth by inducing newly formed blood vessels(neoangiogenesis) that sustain tumor cell …

PROSTAGLANDINSand glucocorticoids are potent mediators of inflammation. Non-steroidal
anti-inflammatory drugs (NSAIDs) exert their effects by inhibition of prostaglandin production…

Nonsteroidal antiinflammatory drugs (NSAIDs) are widely used for the treatment of inflammatory
diseases, but significant side effects such as gastrointestinal erosion and renal damage …

We have examined the role of cyclooxygenase 2 (COX-2) in a model of inflammation in vivo.
Carrageenan administration to the subcutaneous rat air pouch induces a rapid …

A series of sulfonamide-containing 1,5-diarylpyrazole derivatives were prepared and evaluated
for their ability to block cyclooxygenase-2 (COX-2) in vitro and in vivo. Extensive structure…

We have evaluated the role of nitric oxide (NO) on the activity of the constitutive and induced
forms of cyclooxygenase (COX; COX-1 and COX-2, respectively). Induction of NO synthase (…

We report here that the bacterial lipopolysaccharide endotoxin induces human blood
monocytes in a time- and dose-dependent manner to release prodigious amounts of …

… and Seibert. K. Expression and selective inhibition of the constitutive and inducible forms
of human … K. Evaluation of cyclooxygenase-2 inhibitor for potential chemopreventive …