Epileptic seizures drive expression of the blood–brain barrier efflux transporter P-glycoprotein
via a glutamate/cyclooxygenase-2 mediated signalling pathway. Targeting this pathway …

The blood-brain barrier is dysfunctional in epilepsy, thereby contributing to seizure genesis
and resistance to antiseizure drugs. Previously, several groups reported that seizures …

Up-regulation of the blood-brain barrier efflux transporter P-glycoprotein in central nervous
system disorders results in restricted brain access and limited efficacy of therapeutic drugs. In …

The progression of β-amyloid deposition in the brains of mice overexpressing Swedish
mutant β-amyloid precursor protein (APP-Swe), a model of Alzheimer disease (AD), was …

A cure for epilepsy is currently not available, and seizure genesis, seizure recurrence, and
resistance to antiseizure drugs remain serious clinical problems. Studies show that the blood–…

Purpose: Based on experimental findings, overexpression of P‐glycoprotein at the blood–brain
barrier has been suggested to be a contributor to pharmacoresistance of the epileptic …

Blood–brain barrier dysfunction in epilepsy contributes to seizures and resistance to antiseizure
drugs. Reports show that seizures increase brain glutamate levels, leading to barrier …

The blood-brain barrier is altered in epilepsy. This includes altered expression of transporters
and metabolic enzymes as well as barrier leakage that have been linked to antiepileptic …

Purpose The aim of this study is to non-invasively assess early, irradiation-induced normal
tissue alterations via metabolic imaging with 3′-deoxy-3′-[ 18 F]fluorothymidine ([ 18 F]FLT)…

This book on Epilepsy was conceived and produced as a source of information on wide range
of issues in epilepsy. We hope that it will help health care providers in daily practices and …