Aging exacerbates impairments of cerebral blood flow autoregulation and cognition in diabetic rats
S Wang, W Lv, H Zhang, Y Liu, L Li, JR Jefferson… - Geroscience, 2020 - Springer
Diabetes mellitus (DM) is a leading risk factor for aging-related dementia; however, the
underlying mechanisms are not well understood. The present study, utilizing a non-obese T2DN …
underlying mechanisms are not well understood. The present study, utilizing a non-obese T2DN …
Sex differences in the structure and function of rat middle cerebral arteries
…, Y Guo, F Jiao, X Fang, JR Jefferson… - American Journal …, 2020 - journals.physiology.org
Epidemiological studies demonstrate that there are sex differences in the incidence,
prevalence, and outcomes of cerebrovascular disease (CVD). The present study compared the …
prevalence, and outcomes of cerebrovascular disease (CVD). The present study compared the …
Impaired renal hemodynamics and glomerular hyperfiltration contribute to hypertension-induced renal injury
…, W Gao, BV Nguyen, JR Jefferson… - American Journal …, 2020 - journals.physiology.org
Recently, we reported a mutation in γ-adducin (ADD3) was associated with an impaired
myogenic response of the afferent arteriole and hypertension-induced chronic kidney disease (…
myogenic response of the afferent arteriole and hypertension-induced chronic kidney disease (…
Role of γ-adducin in actin cytoskeleton rearrangements in podocyte pathophysiology
We recently reported that the enhanced susceptibility to chronic kidney disease (CKD) in the
fawn-hooded hypertensive (FHH) rat is caused, at least in part, by a mutation in γ-adducin (…
fawn-hooded hypertensive (FHH) rat is caused, at least in part, by a mutation in γ-adducin (…
Impact of knockout of dual-specificity protein phosphatase 5 on structural and mechanical properties of rat middle cerebral arteries: implications for vascular aging
Vascular aging influences hemodynamics, elevating risks for vascular diseases and dementia.
We recently demonstrated that knockout (KO) of Dusp5 enhances cerebral and renal …
We recently demonstrated that knockout (KO) of Dusp5 enhances cerebral and renal …
Knockout of γ-adducin promotes NG-nitro-L-arginine-methyl-ester–induced hypertensive renal injury
Previous studies identified a region on chromosome 1 associated with N G -nitro-L-arginine
methyl ester (L-NAME) hypertension-induced renal disease in fawn-hooded hypertensive (…
methyl ester (L-NAME) hypertension-induced renal disease in fawn-hooded hypertensive (…
Delayed Systemic Treatment with Cannabinoid Receptor 2 Agonist Mitigates Spinal Cord Injury-Induced Osteoporosis More Than Acute Treatment Directly after Injury
…, SMS Marocho, RJ Jackson, JR Jefferson… - Neurotrauma …, 2021 - liebertpub.com
Nearly all persons with spinal cord injury (SCI) will develop osteoporosis following injury,
and further, up to 50% of all persons with SCI will sustain a fracture during their lives. The …
and further, up to 50% of all persons with SCI will sustain a fracture during their lives. The …
Role of Dusp5 KO on Vascular Properties of Middle Cerebral Artery in Rats
…, H Zhang, JJ Border, Y Liu, X Fang, JR Jefferson… - bioRxiv, 2023 - biorxiv.org
Vascular aging influences hemodynamics, elevating risks for vascular diseases and dementia.
We recently demonstrated that knockout (KO) of Dusp5 enhances cerebral and renal …
We recently demonstrated that knockout (KO) of Dusp5 enhances cerebral and renal …
Statement of Permission
JR Jefferson, Y Guo, M Li, W Gao… - … 2 Inhibitor Reverses …, 2020 - search.proquest.com
Diabetes mellitus (DM) is a leading risk factor for aging-related dementia; however, the
underlying mechanisms are not well understood. The present study, utilizing a nonobese T2DN …
underlying mechanisms are not well understood. The present study, utilizing a nonobese T2DN …
Abstract MP46: Knockout Of Add3 Impairs Autoregulation Of Renal Blood Flow And Promotes Hypertension-induced Renal Injury By Increasing Glomerular Capillary …
Recently, we reported that a mutation in γ-Adducin (ADD3) alters the actin cytoskeleton and
is associated with an impaired myogenic response of the afferent arteriole and enhanced …
is associated with an impaired myogenic response of the afferent arteriole and enhanced …