BACKGROUND The aim of this study was to determine the safety and efficacy of intraarterial
chemotherapy with osmotic opening of the blood‐brain barrier (BBB) for the treatment of …

High‐dose busulfan is frequently used in a variety of conditioning regimens for hematopoietic
cell transplantation. In this setting, busulfan has marked neurotoxicity, specifically causing …

Carboplatin is effective in the treatment of malignant brain tumors. However, when administered
in conjunction with osmotic opening of the blood-brain barrier (BBB), carboplatin is …

Sodium thiosulfate (STS) provides protection against carboplatin-induced ototoxicity in an
animal model. The purpose of this study was to determine the STS dose required for …

Posaconazole tablet formulation ( PTF ) was developed to optimise bioavailability. This
study compared posaconazole levels between patients on the PTF and oral suspension …

Introduction Calcineurin inhibitors are commonly used in hematopoietic stem cell transplant
(HSCT) patients to prevent graft versus host disease, but as CYP3A4 substrates they are …

Daptomycin is the first antibacterial agent of the cyclic lipopeptides with in vitro bactericidal
activity against gram-positive organisms, including vancomycin-resistant enterococci, …

Aprepitant, a neurokinin antagonist, is an effective antiemetic agent in chemotherapy for
delayed nausea and vomiting. The study objective was to evaluate the pharmacokinetics of …

Graft-versus-host disease after liver transplantation (LT-GVHD) is rare, frequently fatal, and
associated with bone marrow failure (BMF), cytopenias, and hyperferritinemia. Given …

Posaconazole is used for prophylaxis for invasive fungal infections (IFIs) among patients
with hematologic malignancies. We compared the incidence of breakthrough IFIs and early …