Methylphenidate actively induces emergence from general anesthesia
Background Although accumulating evidence suggests that arousal pathways in the brain
play important roles in emergence from general anesthesia, the roles of monoaminergic …
play important roles in emergence from general anesthesia, the roles of monoaminergic …
Potent activation of the human tandem pore domain K channel TRESK with clinical concentrations of volatile anesthetics
C Liu, JD Au, HL Zou, JF Cotten… - Anesthesia & Analgesia, 2004 - journals.lww.com
IMPLICATIONS: Enhancement of background K channel currents by volatile anesthetics
may contribute to neuronal depression during anesthesia. Currents passed by a newly …
may contribute to neuronal depression during anesthesia. Currents passed by a newly …
Methoxycarbonyl-etomidate: A Novel Rapidly Metabolized and Ultra–short-acting Etomidate Analogue that Does Not Produce Prolonged Adrenocortical Suppression
JF Cotten, SS Husain, SA Forman… - The Journal of the …, 2009 - pubs.asahq.org
Background Etomidate is a rapidly acting sedative-hypnotic that provides hemodynamic
stability. It causes prolonged suppression of adrenocortical steroid synthesis; therefore, its …
stability. It causes prolonged suppression of adrenocortical steroid synthesis; therefore, its …
Carboetomidate: a pyrrole analog of etomidate designed not to suppress adrenocortical function
Background Etomidate is a sedative hypnotic that is often used in critically ill patients because
it provides superior hemodynamic stability. However, it also binds with high affinity to …
it provides superior hemodynamic stability. However, it also binds with high affinity to …
The ventilatory stimulant doxapram inhibits TASK tandem pore (K2P) potassium channel function but does not affect minimum alveolar anesthetic concentration
JF Cotten, B Keshavaprasad, MJ Laster… - Anesthesia & …, 2006 - journals.lww.com
IMPLICATIONS: This study demonstrates that TASK potassium channels are plausible
molecular targets for doxapram yet do not contribute to halothane-induced immobility (minimum …
molecular targets for doxapram yet do not contribute to halothane-induced immobility (minimum …
[HTML][HTML] Cystic fibrosis-associated mutations at arginine 347 alter the pore architecture of CFTR: evidence for disruption of a salt bridge
JF Cotten, MJ Welsh - Journal of Biological Chemistry, 1999 - ASBMB
Arginine 347 in the sixth transmembrane domain of cystic fibrosis transmembrane
conductance regulator (CFTR) is a site of four cystic fibrosis-associated mutations. To better …
conductance regulator (CFTR) is a site of four cystic fibrosis-associated mutations. To better …
TASK-1 (KCNK3) and TASK-3 (KCNK9) tandem pore potassium channel antagonists stimulate breathing in isoflurane-anesthetized rats
JF Cotten - Anesthesia & Analgesia, 2013 - journals.lww.com
BACKGROUND: TASK-1 and TASK-3 tandem pore potassium channel subunits provide a
constitutive acidic pH-and hypoxia-inhibited potassium conductance. TASK channels are …
constitutive acidic pH-and hypoxia-inhibited potassium conductance. TASK channels are …
[HTML][HTML] Effect of cystic fibrosis-associated mutations in the fourth intracellular loop of cystic fibrosis transmembrane conductance regulator
JF Cotten, LS Ostedgaard, MR Carson… - Journal of Biological …, 1996 - ASBMB
The cystic fibrosis transmembrane conductance regulator (CFTR) contains multiple membrane
spanning sequences that form a Cl − channel pore and cytosolic domains that control the …
spanning sequences that form a Cl − channel pore and cytosolic domains that control the …
5‐Hydroxytryptophan, a precursor for serotonin synthesis, reduces seizure‐induced respiratory arrest
H Zhang, H Zhao, X Yang, Q Xue, JF Cotten… - …, 2016 - Wiley Online Library
Objective The DBA/1 mouse is a relevant animal model of sudden unexpected death in
epilepsy (SUDEP), as it exhibits seizure‐induced respiratory arrest (S‐IRA) evoked by acoustic …
epilepsy (SUDEP), as it exhibits seizure‐induced respiratory arrest (S‐IRA) evoked by acoustic …
Fluoxetine prevents respiratory arrest without enhancing ventilation in DBA/1 mice
Sudden unexpected death in epilepsy (SUDEP) is a fatal epileptic event. DBA/1 mice are a
relevant animal model for the study of SUDEP, as these mice exhibit seizure-induced …
relevant animal model for the study of SUDEP, as these mice exhibit seizure-induced …