Activating mutations in the genes for fibroblast growth factor receptors 1–3 (FGFR1–3) are
responsible for a diverse group of skeletal disorders. In general, mutations in FGFR1 and …

10.7554/eLife.16220.001 Although it is clear that trisomy 21 causes Down syndrome, the
molecular events acting downstream of the trisomy remain ill defined. Using complementary …

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder with a complex
pathogenesis. Diarrhea is a highly prevalent and often debilitating symptom of IBD patients that …

Amiodarone causes thyrotoxicosis in 3% of US patients who use it. Two types of amiodarone-induced
thyrotoxicosis are recognized, designated type 1 and type 2, based on whether or …

10.7554/eLife.40228.001 The mechanisms by which mammalian cells recognize and
epigenetically restrict viral DNA are not well defined. We used herpes simplex virus with …

This study examined age-related changes in renal dopaminergic activity and expression of
amino acid transporters potentially involved in renal tubular uptake of l-DOPA in Wistar Kyoto …

Mycobacterium avium subsp. paratuberculosis (MAP) has long been implicated as a triggering
agent in Crohn’s disease (CD). In this study, we investigated the growth/persistence of …

Type 2 Toll-like receptors (TLR2s) are expressed in cell membranes and recognize a wide
range of pathogen-associated molecular patterns derived from bacteria, such as lipoteichoic …

Inappropriate activation of pattern recognition receptors has been described as a potential
trigger in the development of inflammatory bowel disease (IBD). In this study, we evaluated …

… José Miguel Cabral … José Miguel Cabral … However, short- and long-term TLR4 activation
might use different signalling pathways (Cabral et al. 2015b). Activation of TLR5 with flagellin …