Toll-like receptor (TLR) 2–9 agonists-induced cytokines and chemokines: I. Comparison with T cell receptor-induced responses
TK Ghosh, DJ Mickelson, J Fink, JC Solberg… - Cellular …, 2006 - Elsevier
The cells of innate and adaptive immunity, although activated by different ligands, engage in
cross talk to ensure a successful immune outcome. To better understand this interaction, we …
cross talk to ensure a successful immune outcome. To better understand this interaction, we …
First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G
…, WL Brown, AL Perkins, DA Harki, J Solberg… - ACS chemical …, 2012 - ACS Publications
APOBEC3G is a single-stranded DNA cytosine deaminase that comprises part of the innate
immune response to viruses and transposons. Although APOBEC3G is the prototype for …
immune response to viruses and transposons. Although APOBEC3G is the prototype for …
TLR–TLR cross talk in human PBMC resulting in synergistic and antagonistic regulation of type-1 and 2 interferons, IL-12 and TNF-α
TK Ghosh, DJ Mickelson, JC Solberg, KE Lipson… - International …, 2007 - Elsevier
Currently, single TLR agonists are being utilized for vaccination and tumor immunotherapy.
Here we investigated the effects of tandem combinations of TLR agonists on the production …
Here we investigated the effects of tandem combinations of TLR agonists on the production …
[HTML][HTML] Hierarchical phosphorylation of δ-opioid receptor regulates agonist-induced receptor desensitization and internalization
O Maestri-El Kouhen, G Wang, J Solberg… - Journal of Biological …, 2000 - ASBMB
Treatment of HEK293 cells expressing the δ-opioid receptor with agonist [d-Pen 2,5 ]enkephalin
(DPDPE) resulted in the rapid phosphorylation of the receptor. We constructed several …
(DPDPE) resulted in the rapid phosphorylation of the receptor. We constructed several …
[HTML][HTML] Heterodimerization of μ-and δ-opioid receptors occurs at the cell surface only and requires receptor-G protein interactions
…, LJ Erickson-Herbrandson, QQ Zha, J Solberg… - Journal of Biological …, 2005 - ASBMB
Homo- and heterodimerization of the opioid receptors with functional consequences were
reported previously. However, the exact nature of these putative dimers has not been identified…
reported previously. However, the exact nature of these putative dimers has not been identified…
Receptor density and recycling affect the rate of agonist-induced desensitization of μ-opioid receptor
…, LJ Erickson, R El-Kouhen, L Dicker, J Solberg… - Molecular …, 2000 - ASPET
Previously, we reported that the time course for the rapid phosphorylation rate of μ-opioid
receptor expressed in human embryonic kidney (HEK)293 cells did not correlate with the slow …
receptor expressed in human embryonic kidney (HEK)293 cells did not correlate with the slow …
Academic emergency physicians' experiences with patient death
…, J Lemos, R Paganelli, J Solberg… - Academic …, 2011 - Wiley Online Library
ACADEMIC EMERGENCY MEDICINE 2011; 18:255–260 © 2011 by the Society for Academic
Emergency Medicine Abstract Objectives: There is a growing awareness of the effects of …
Emergency Medicine Abstract Objectives: There is a growing awareness of the effects of …
[HTML][HTML] Deltorphin II-induced rapid desensitization of δ-opioid receptor requires both phosphorylation and internalization of the receptor
PY Law, O Maestri-El Kouhen, J Solberg… - Journal of Biological …, 2000 - ASBMB
Similar to other G protein-coupled receptors, rapid phosphorylation of the δ-opioid receptor
in the presence of agonist has been reported. Hence, agonist-induced desensitization of the …
in the presence of agonist has been reported. Hence, agonist-induced desensitization of the …
[HTML][HTML] A cell-free fluorometric high-throughput screen for inhibitors of Rtt109-catalyzed histone acetylation
The lysine acetyltransferase (KAT) Rtt109 forms a complex with Vps75 and catalyzes the
acetylation of histone H3 lysine 56 (H3K56ac) in the Asf1-H3-H4 complex. Rtt109 and …
acetylation of histone H3 lysine 56 (H3K56ac) in the Asf1-H3-H4 complex. Rtt109 and …
Identification of novel non-hydroxamate anthrax toxin lethal factor inhibitors by topomeric searching, docking and scoring, and in vitro screening
TL Chiu, J Solberg, S Patil, TW Geders… - Journal of chemical …, 2009 - ACS Publications
Anthrax is an infectious disease caused by Bacillus anthracis, a Gram-positive, rod-shaped,
anaerobic bacterium. The lethal factor (LF) enzyme is secreted by B. anthracis as part of a …
anaerobic bacterium. The lethal factor (LF) enzyme is secreted by B. anthracis as part of a …