User profiles for Jonathan D Wren

Jonathan Wren

Bioinformatics Core Director & Associate Member, Oklahoma Medical Research Foundation
Verified email at omrf.org
Cited by 13561

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs

…, CM Roos, GC Verzosa, NK LeBrasseur, JD Wren… - Aging cell, 2015 - Wiley Online Library
The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide
gene. Achieving the same using small molecules would have a tremendous impact on quality …

Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors

…, N Giorgadze, KO Johnson, CB Giles, JD Wren… - Aging cell, 2016 - Wiley Online Library
Clearing senescent cells extends healthspan in mice. Using a hypothesis‐driven
bioinformatics‐based approach, we recently identified pro‐survival pathways in human senescent …

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome

…, DM Lewis, L Radfar, MD Rohrer, DU Stone, JD Wren… - Nature …, 2013 - nature.com
Sjögren's syndrome is a common autoimmune disease (affecting ∼0.7% of European
Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we report …

Endothelial dysfunction and angiogenesis impairment in the ageing vasculature

Z Ungvari, S Tarantini, T Kiss, JD Wren… - Nature Reviews …, 2018 - nature.com
Ageing is the main risk factor for the development of cardiovascular diseases. A central
mechanism by which ageing promotes vascular pathologies is compromising endothelial health. …

Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naive CD4+ T cells from lupus …

…, N Altorok, MG Dozmorov, KA Koelsch, JD Wren… - Journal of …, 2013 - Elsevier
Systemic lupus erythematosus is an autoimmune disease characterized by multi-system
involvement and autoantibody production. Abnormal T cell DNA methylation and type-I …

[HTML][HTML] The write position: A survey of perceived contributions to papers based on byline position and number of authors

JD Wren, KZ Kozak, KR Johnson, SJ Deakyne… - EMBO …, 2007 - embopress.org
Publications in peer-reviewed journals are a major criterion for assessing scientists for promotion,
tenure or funding (Beasley & Wright, 2003; Thomas et al, 2004). Yet, there are different …

[HTML][HTML] The role of DNA methylation in epigenetics of aging

…, WM Freeman, J Jackson, JD Wren… - Pharmacology & …, 2019 - Elsevier
Recent research suggests that epigenetics, especially DNA methylation, plays a mechanistic
role in aging. Epigenetic clocks, which measure changes in a few hundred specific CpG …

Knowledge discovery by automated identification and ranking of implicit relationships

JD Wren, R Bekeredjian, JA Stewart, RV Shohet… - …, 2004 - academic.oup.com
Motivation: New relationships are often implicit from existing information, but the amount and
growth of published literature limits the scope of analysis an individual can accomplish. Our …

Genome-wide DNA methylation patterns in CD4+ T cells from patients with systemic lupus erythematosus

M Jeffries, M Dozmorov, Y Tang, JT Merrill, JD Wren… - Epigenetics, 2011 - Taylor & Francis
Systemic lupus erythematosus is a chronic-relapsing autoimmune disease of incompletely
understood etiology. Recent evidence strongly supports an epigenetic contribution to the …

High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry

…, BG Han, M Dozmorov, KM Kaufman, JD Wren… - Nature …, 2016 - nature.com
Systemic lupus erythematosus (SLE) has a strong but incompletely understood genetic
architecture. We conducted an association study with replication in 4,478 SLE cases and 12,656 …