User profiles for John M. Rimoldi

John Rimoldi

Professor of Medicinal Chemistry, University of Mississippi
Verified email at olemiss.edu
Cited by 3544

The structure–function relationships of classical cannabinoids: CB1/CB2 modulation

EW Bow, JM Rimoldi - Perspectives in medicinal chemistry, 2016 - journals.sagepub.com
The cannabinoids are members of a deceptively simple class of terpenophenolic secondary
metabolites isolated from Cannabis sativa highlighted by (-)-Δ 9 -tetrahydrocannabinol (THC…

Protective effect of carbon monoxide–releasing compounds in ischemia-induced acute renal failure

…, JR Henegar, HA Drummond, JM Rimoldi… - Journal of the …, 2005 - journals.lww.com
Heme oxygenase (HO) induction has been demonstrated to be beneficial in limiting the extent
of cellular damage after ischemia-induced acute renal failure (ARF). Because increased …

Anticancer activity of natural and synthetic capsaicin analogs

…, KW Colclough, JM Seidler, JM Rimoldi… - … of Pharmacology and …, 2018 - ASPET
The nutritional compound capsaicin is the major spicy ingredient of chili peppers. Although
traditionally associated with analgesic activity, recent studies have shown that capsaicin has …

Renal vascular responses to CORM-A1 in the mouse

…, HA Drummond, GR McLemore Jr, JM Rimoldi… - Pharmacological …, 2006 - Elsevier
CORM-A1 is a newly described water-soluble carbon monoxide (CO) releasing molecule (CORM)
that can deliver CO to various vascular beds in the absence of dramatic changes in …

Anticancer activity of region B capsaicin analogs

…, TE Long, RS Gadepalli, JM Rimoldi… - Journal of Medicinal …, 2023 - ACS Publications
The heterocyclic vanilloid compound capsaicin is responsible for the spicy and pungent
flavor of chili peppers. Several convergent studies have shown that capsaicin suppresses the …

Marine proteomics: a critical assessment of an emerging technology

…, DJ Gochfeld, KL Willett, JM Rimoldi - Journal of natural …, 2012 - ACS Publications
The application of proteomics to marine sciences has increased in recent years because the
proteome represents the interface between genotypic and phenotypic variability and, thus, …

Synthesis and biological evaluation of 2-acyl analogues of paclitaxel (Taxol)

…, AAL Gunatilaka, PI Higgs, JM Rimoldi… - Journal of medicinal …, 1998 - ACS Publications
The anticancer drug paclitaxel (Taxol) has been converted to a large number of 2-debenzoyl-2-aroyl
derivatives by three different methods. The bioactivities of the resulting analogues …

In vitro and in vivo studies on stilbene analogs as potential treatment agents for colon cancer

…, HJ Lee, X Zheng, S Chajkowisk, JM Rimoldi… - European journal of …, 2010 - Elsevier
Based on the potential of resveratrol as a colon cancer chemopreventive agent, a set of 26
stilbenes were synthesized and tested against the colon cancer cell lines HT-29 and Caco-2. (…

Unexpectedly facile hydrolysis of the 2-benzoate group of taxol and syntheses of analogs with increased activities

AG Chaudhary, MM Gharpure, JM Rimoldi… - Journal of the …, 1994 - ACS Publications
The diterpenoid taxol (1), first isolated from Taxus brevifolia, 1 has excellent clinicalactivity
against ovarian and breast cancers and shows promise in the treatment of other cancers. 2 …

Anti-cryptococcal and nitric oxide synthase inhibitory imidazole alkaloids from the calcareous sponge Leucetta cf chagosensis

DC Dunbar, JM Rimoldi, AM Clark, M Kelly… - Tetrahedron, 2000 - Elsevier
Antifungal imidazole alkaloids were isolated from the Egyptian Red Sea sponge Leucetta cf
chagosensis using HPLC. These compounds were the previously reported naamidine A, B, …