Confirmation of the hierarchical folding of RNase H: a protein engineering study
TM Raschke, J Kho, S Marqusee - Nature structural biology, 1999 - nature.com
The kinetic intermediate of RNase H is structured in a core region of the protein. To probe
the role of this intermediate in the folding of RNase H, the folding kinetics of mutant proteins …
the role of this intermediate in the folding of RNase H, the folding kinetics of mutant proteins …
A suicidal strain of Listeria monocytogenes is effective as a DNA vaccine delivery system for oral administration
S Sinha, CY Kuo, JK Ho, PJ White, JA Jazayeri… - Vaccine, 2017 - Elsevier
In this study we determined the in vivo activity of model ovalbumin vaccines delivered by
direct intramuscular delivery of plasmid DNA or oral delivery using a recombinant suicidal …
direct intramuscular delivery of plasmid DNA or oral delivery using a recombinant suicidal …
[HTML][HTML] Self-crosslinking lipopeptide/DNA/PEGylated particles: a new platform for DNA vaccination designed for assembly in aqueous solution
Delivery of plasmids for gene expression in vivo is an inefficient process that requires
improvement and optimization to unlock the clinical potential of DNA vaccines. With ease of …
improvement and optimization to unlock the clinical potential of DNA vaccines. With ease of …
[HTML][HTML] Inhibition of β-catenin dependent WNT signalling upregulates the transcriptional repressor NR0B1 and downregulates markers of an A9 phenotype in human …
In this study we investigate how β-catenin-dependent WNT signalling impacts midbrain
dopaminergic neuron (mDA) specification. mDA cultures at day 65 of differentiation responded to …
dopaminergic neuron (mDA) specification. mDA cultures at day 65 of differentiation responded to …
Induced pluripotent stem cell–derived podocyte-like cells as models for assessing mechanisms underlying heritable disease phenotype: initial studies using two Alport …
…, IPL Abad, JK Ho, WL Lieuw, K Leach… - … of Pharmacology and …, 2018 - ASPET
Renal podocyte survival depends upon the dynamic regulation of a complex cell architecture
that links the glomerular basement membrane to integrins, ion channels, and receptors. …
that links the glomerular basement membrane to integrins, ion channels, and receptors. …
[HTML][HTML] TGFβ3, dibutyryl cAMP and a notch inhibitor modulate phenotype late in stem cell-derived dopaminergic neuron maturation
The generation of midbrain dopaminergic neurons (mDAs) from pluripotent stem cells (hPSC)
holds much promise for both disease modelling studies and as a cell therapy for Parkinson…
holds much promise for both disease modelling studies and as a cell therapy for Parkinson…
mRNA vaccines encoding membrane-anchored receptor-binding domains of SARS-CoV-2 mutants induce strong humoral responses and can overcome immune …
…, SA Fabb, SL Grimley, R Kochappan, JK Ho… - bioRxiv, 2023 - biorxiv.org
To address the limitations of whole-spike COVID vaccines, we explored mRNA vaccines
encoding membrane-anchored receptor-binding domain (RBD-TMs), each a fusion of a variant …
encoding membrane-anchored receptor-binding domain (RBD-TMs), each a fusion of a variant …
[HTML][HTML] Tissue-specific calibration of real-time pcr facilitates absolute quantification of plasmid DNA in biodistribution studies
Analysis of the tissue distribution of plasmid DNA after administration of nonviral gene
delivery systems is best accomplished using quantitative real-time polymerase chain reaction (…
delivery systems is best accomplished using quantitative real-time polymerase chain reaction (…
Strengthening resilience in over 50's: A nested clustered-randomized controlled trial of adaptive systematic self-reflection
Background and objectives: This study investigated the efficacy of guided self-reflection to
strengthen resilience in adults over 50 by exploring the effects of the training on mental health …
strengthen resilience in adults over 50 by exploring the effects of the training on mental health …
CD14 tobacco gene–environment interaction modifies asthma severity and immunoglobulin E levels in Latinos with asthma
…, PC Avila, S Nazario, N Ung, J Kho… - American journal of …, 2005 - atsjournals.org
Background: A recent family-based genomewide screen revealed linkage between the 5q31
region and the diagnosis of asthma, but only in those exposed to environmental tobacco …
region and the diagnosis of asthma, but only in those exposed to environmental tobacco …