R ecent evidence supplies new insights regarding the two universal effects of inhaled
anesthetics: 1) immobility in response to a noxious stimulus and 2) amnesia. We hypothesize that …

Barbiturates are often described as non-analgesic or even hyperalgesic agents; the newer
intravenous anesthetic agent propofol is said to be non-analgesic. Both propofol and …

The behavioral state known as general anesthesia is the result of actions of general anesthetic
agents at multiple sites within the neuraxis. The most common end point used to measure …

The central nervous system undergoes dynamic changes as it matures. However, until
recently, very little was known about the impact of these changes on pain and analgesia. This …

Background The spinal cord is an important anatomic site at which volatile agents act to
prevent movement in response to a noxious stimulus. This study was designed to test the …

Voltage clamp experiments were carried out on Rana catesbiana nodes of Ranvier in order
to test predictions regarding the relationship between local anesthetic lipid solubility and the …

α 2 -Adrenoceptors mediate analgesia in vivo. The present study explored the actions of the
α 2 -adrenoceptor agonists dexmedetomidine and clonidine on a nociceptive response in …

On withdrawal from opioids many patients experience a heightened sensitivity to stimuli and
an exaggerated pain response. The phenomenon has been little studied in infants. We …

Ethanol (EtOH) withdrawal increases sensitivity to painful stimuli in adult rats. In this study,
withdrawal from a single, acute administration of EtOH dose-dependently produced …

Our laboratory has previously characterized age-dependent changes in nociception upon
acute morphine withdrawal. This study characterizes changes in mechanical and thermal …