Role of P-glycoprotein in pharmacokinetics: clinical implications
JH Lin, M Yamazaki - Clinical pharmacokinetics, 2003 - Springer
P-glycoprotein, the most extensively studied ATP-binding cassette (ABC) transporter, functions
as a biological barrier by extruding toxins and xenobiotics out of cells. In vitro and in vivo …
as a biological barrier by extruding toxins and xenobiotics out of cells. In vitro and in vivo …
Inhibition and induction of cytochrome P450 and the clinical implications
JH Lin, AYH Lu - Clinical pharmacokinetics, 1998 - Springer
The cytochrome P450s (CYPs) constitute a superfamily of isoforms that play an important role
in the oxidative metabolism of drugs. Each CYP isoform possesses a characteristic broad …
in the oxidative metabolism of drugs. Each CYP isoform possesses a characteristic broad …
Role of pharmacokinetics and metabolism in drug discovery and development
JH Lin, AYH Lu - Pharmacological reviews, 1997 - ASPET
Drug research encompasses several diverse disciplines united by a common goal, namely
the development of novel therapeutic agents. The search for new drugs can be divided …
the development of novel therapeutic agents. The search for new drugs can be divided …
Is the role of the small intestine in first-pass metabolism overemphasized?
JH Lin, M Chiba, TA Baillie - Pharmacological reviews, 1999 - ASPET
The primary function of the small intestine is to absorb nutrients and water. This is achieved
by mixing food with digestive enzymes to increase the contact of foodstuffs with the …
by mixing food with digestive enzymes to increase the contact of foodstuffs with the …
[PDF][PDF] Species similarities and differences in pharmacokinetics.
JH Lin - Drug Metabolism and Disposition, 1995 - Citeseer
One of the fundamental challenges drug metabolism scientists face in drug discovery and
development is the extrapolation of metabolic data and risk assessment from animals to …
development is the extrapolation of metabolic data and risk assessment from animals to …
Drug–drug interaction mediated by inhibition and induction of P-glycoprotein
JH Lin - Advanced drug delivery reviews, 2003 - Elsevier
P-glycoprotein (P-gp), the most extensively studied ATP-binding cassette transporter, functions
as a biological barrier by extruding toxic substances and xenobiotics out of cells. In vitro …
as a biological barrier by extruding toxic substances and xenobiotics out of cells. In vitro …
Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization
…, R Subramanian, X Fang, B Ma, Y Qiu, JH Lin… - Drug Metabolism and …, 2002 - ASPET
The active forms of all marketed hydroxymethylglutaryl (HMG)-CoA reductase inhibitors
share a common dihydroxy heptanoic or heptenoic acid side chain. In this study, we present …
share a common dihydroxy heptanoic or heptenoic acid side chain. In this study, we present …
A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase
…, AS Espeseth, L Jin, IW Chen, JH Lin… - Proceedings of the …, 2004 - National Acad Sciences
The increasing incidence of resistance to current HIV-1 therapy underscores the need to
develop antiretroviral agents with new mechanisms of action. Integrase, one of three viral …
develop antiretroviral agents with new mechanisms of action. Integrase, one of three viral …
Interindividual variability in inhibition and induction of cytochrome P450 enzymes
JH Lin, AYH Lu - Annual review of pharmacology and toxicology, 2001 - annualreviews.org
Drug interactions have always been a major concern in medicine for clinicians and patients.
Inhibition and induction of cytochrome P450 (CYP) enzymes are probably the most common …
Inhibition and induction of cytochrome P450 (CYP) enzymes are probably the most common …
Effects of fibrates on metabolism of statins in human hepatocytes
…, C Tang, Y Qiu, L Mu, R Subramanian, JH Lin - Drug Metabolism and …, 2002 - ASPET
This study investigated the metabolic interaction between fibrates and statin hydroxy acids
in human hepatocytes. Gemfibrozil (GFZ) modestly affected the formation of β-oxidative …
in human hepatocytes. Gemfibrozil (GFZ) modestly affected the formation of β-oxidative …