Antinociceptive effects of central administration of the endogenous cannabinoid receptor type 1 agonist VDPVNFKLLSH-OH [(m) VD-hemopressin (α)], an N-terminally …
The cannabinoid system has been demonstrated to modulate the acute and chronic pain of
multiple origins. Mouse VD-hemopressin(α) [(m)VD-Hpα], an 11-residue α-hemoglobin–…
multiple origins. Mouse VD-hemopressin(α) [(m)VD-Hpα], an 11-residue α-hemoglobin–…
Structure-based optimization of multifunctional agonists for opioid and neuropeptide FF receptors with potent nontolerance forming analgesic activities
The opioid and neuropeptide FF pharmacophore-containing chimeric peptide 0 (BN-9) was
recently developed and produced potent nontolerance forming analgesia. In this study, 11 …
recently developed and produced potent nontolerance forming analgesia. In this study, 11 …
[HTML][HTML] Effects of repetitive peripheral magnetic stimulation on spasticity evaluated with modified Ashworth scale/Ashworth scale in patients with spastic paralysis: A …
JX Pan, YX Diao, HY Peng, XZ Wang, LR Liao… - Frontiers in …, 2022 - frontiersin.org
Background Spasticity is a common motor disorder resulting from upper motor neuron lesions.
It has a serious influence on an individual's motor function and daily activity. Repetitive …
It has a serious influence on an individual's motor function and daily activity. Repetitive …
Analgesic tolerance and cross-tolerance to the cannabinoid receptors ligands hemopressin, VD-hemopressin (α) and WIN55, 212-2 at the supraspinal level in mice
The nonapeptide hemopressin and its N-terminal extension VD-hemopressin(α) were reported
as an antagonist/inverse agonist and an agonist of CB 1 receptor, respectively. These …
as an antagonist/inverse agonist and an agonist of CB 1 receptor, respectively. These …
[HTML][HTML] A modified nucleoside O6-methyl-2′-deoxyguanosine-5′-triphosphate exhibits anti-glioblastoma activity in a caspase-independent manner
…, QQ Li, QY Wang, LT Zeng, SJ Li, X Gao, JX Pan… - Pharmacological …, 2024 - Elsevier
Resistance to temozolomide (TMZ), the frontline chemotherapeutic agent for glioblastoma (GBM),
has emerged as a formidable obstacle, underscoring the imperative to identify …
has emerged as a formidable obstacle, underscoring the imperative to identify …
[HTML][HTML] Opposite effects of neuropeptide FF on central antinociception induced by endomorphin-1 and endomorphin-2 in mice
Neuropeptide FF (NPFF) is known to be an endogenous opioid-modulating peptide.
Nevertheless, very few researches focused on the interaction between NPFF and endogenous …
Nevertheless, very few researches focused on the interaction between NPFF and endogenous …
Incubating green turtle (Chelonia mydas) eggs at constant temperatures: Hatching success, hatchling morphology and post-hatch growth
YT Yao, Y Du, JX Pan, CX Lin, X Ji, WH You - Journal of Thermal Biology, 2022 - Elsevier
Past studies applying constant-temperature incubation of eggs have involved all species of
sea turtles, but rarely can we find a single one incubating eggs at three or more temperatures…
sea turtles, but rarely can we find a single one incubating eggs at three or more temperatures…
Neuropeptide VF enhances cannabinoid agonist WIN55, 212-2-induced antinociception in mice
BACKGROUND: Cannabinoids produce analgesia in several pain models, but the undesirable
side effects from high doses of cannabinoid drugs limit their clinic use. Our recent results …
side effects from high doses of cannabinoid drugs limit their clinic use. Our recent results …
The hypotensive effect of intrathecally injected (m) VD-hemopressin (α) in urethane-anesthetized rats
Previous studies suggest that cannabinoids system plays an important role in cardiovascular
regulation. (m)VD-hemopressin(α) (VD-Hpα), an 11-residue peptide originating from the α …
regulation. (m)VD-hemopressin(α) (VD-Hpα), an 11-residue peptide originating from the α …
Effects of neuropeptide FF and related peptides on the antinociceptive activities of VD-hemopressin (α) in naive and cannabinoid-tolerant mice
Neuropeptide FF (NPFF) system has recently been reported to modulate cannabinoid-induced
antinociception. The aim of the present study was to further investigate the roles of NPFF …
antinociception. The aim of the present study was to further investigate the roles of NPFF …