User profiles for Jesse Lo Verme
Jesse LoVerme, Ph.D.UC, Irvine Verified email at alumni.uci.edu Cited by 5397 |
The search for the palmitoylethanolamide receptor
J LoVerme, G La Rana, R Russo, A Calignano… - Life sciences, 2005 - Elsevier
Palmitoylethanolamide (PEA), the naturally occurring amide of ethanolamine and palmitic
acid, is an endogenous lipid that modulates pain and inflammation. Although the anti-…
acid, is an endogenous lipid that modulates pain and inflammation. Although the anti-…
Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α
Oleylethanolamide (OEA) is a naturally occurring lipid that regulates satiety and body weight
1 , 2 . Although structurally related to the endogenous cannabinoid anandamide, OEA does …
1 , 2 . Although structurally related to the endogenous cannabinoid anandamide, OEA does …
The nuclear receptor peroxisome proliferator-activated receptor-α mediates the anti-inflammatory actions of palmitoylethanolamide
JL Verme, J Fu, G Astarita, G La Rana, R Russo… - Molecular …, 2005 - ASPET
Palmitoylethanolamide (PEA), the naturally occurring amide of palmitic acid and ethanolamine,
reduces pain and inflammation through an as-yet-uncharacterized mechanism. Here, we …
reduces pain and inflammation through an as-yet-uncharacterized mechanism. Here, we …
[HTML][HTML] Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor α (PPAR-α)
M Guzmán, JL Verme, J Fu, F Oveisi… - Journal of biological …, 2004 - ASBMB
Amides of fatty acids with ethanolamine (FAE) are biologically active lipids that participate in
a variety of biological functions, including the regulation of feeding. The polyunsaturated …
a variety of biological functions, including the regulation of feeding. The polyunsaturated …
Rapid pain modulation with nuclear receptor ligands
We discuss and present new data regarding the physiological and molecular mechanisms
of nuclear receptor activation in pain control, with a particular emphasis on non-genomic …
of nuclear receptor activation in pain control, with a particular emphasis on non-genomic …
Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-κB nuclear signalling in dorsal root ganglia
Despite the clear roles played by peroxisome proliferators-activated receptor α (PPAR-α) in
lipid metabolism, inflammation and feeding, the effects of its activation in the central nervous …
lipid metabolism, inflammation and feeding, the effects of its activation in the central nervous …
Rapid broad-spectrum analgesia through activation of peroxisome proliferator-activated receptor-α
J LoVerme, R Russo, G La Rana, J Fu, J Farthing… - … of Pharmacology and …, 2006 - ASPET
Severe pain remains a major area of unmet medical need. Here we report that agonists of
the nuclear receptor PPAR-α (peroxisome proliferator-activated receptor-α) suppress pain …
the nuclear receptor PPAR-α (peroxisome proliferator-activated receptor-α) suppress pain …
Acute intracerebroventricular administration of palmitoylethanolamide, an endogenous peroxisome proliferator-activated receptor-α agonist, modulates carrageenan …
…, E Esposito, GM Raso, S Cuzzocrea, JL Verme… - … of Pharmacology and …, 2007 - ASPET
Peroxisome proliferator-activated receptor (PPAR)-α is a nuclear transcription factor. Although
the presence of this receptor in different areas of central nervous system (CNS) has been …
the presence of this receptor in different areas of central nervous system (CNS) has been …
The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3′-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in …
R Russo, J LoVerme, G La Rana, TR Compton… - … of Pharmacology and …, 2007 - ASPET
Fatty acid amide hydrolase (FAAH) is an intracellular serine hydrolase that catalyzes the
cleavage of bioactive fatty acid ethanolamides, such as the endogenous cannabinoid agonist …
cleavage of bioactive fatty acid ethanolamides, such as the endogenous cannabinoid agonist …
Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice
Cannabinoid CB 1 receptor antagonists reduce body weight in rodents and humans, but their
clinical utility as anti-obesity agents is limited by centrally mediated side effects. Here, we …
clinical utility as anti-obesity agents is limited by centrally mediated side effects. Here, we …