TLR4 is a member of the recently identified Toll-like receptor family of proteins and has been
putatively identified as Lps, the gene necessary for potent responses to lipopolysaccharide …

Cellular fibronectin, which contains an alternatively spliced exon encoding type III repeat
extra domain A (EDA), is produced in response to tissue injury. Fragments of fibronectin have …

Somatic cell mutagenesis is a powerful tool for characterizing receptor systems. We
reported previously two complementation groups of mutant cell lines derived from CD14-transfected …

Lipopolysaccharide (LPS) stimulates multiple signaling events, including nuclear factor-κB (NF-κB)
activity and the mitogen-activated protein (MAP) kinases, ERK, JNK, and p38 in LPS-…

… involves the cell surface receptor for LPS previously described as TLR4 (Chow et al., 1999).
… Chow, unpublished data). These results suggest that E5564 interferes with LPS signaling at …

The discovery that circulating nucleic acid-containing complexes in the serum of autoimmune
lupus patients can stimulate B cells and plasmacytoid dendritic cells via Toll-like receptors …

Muscle-invasive bladder cancer (MIBC) is an aggressive disease with limited therapeutic
options. Although immunotherapies are approved for MIBC, the majority of patients fail to …

Respiratory syncytial virus (RSV) is a leading cause of infant mortality worldwide. Toll-like
receptor 4 (TLR4), a signaling receptor for structurally diverse microbe-associated molecular …

Insulin-like growth factor-I (IGF-I) receptors activate divergent signaling pathways by
phosphorylating multiple cellular proteins, including insulin receptor substrate-1 (IRS-1) and the Shc …

Objective— Oxidized phospholipids (OxPLs) that are abundant in atherosclerotic lesions are
increasingly recognized as context-dependent lipid mediators demonstrating both pro- and …