These studies have revealed that the delivery and actions of beta receptor antagonist drugs
are controlled by a cascade of stereoselective processes involving multiple enzymes, …

Adenylyl cyclases present a potential focal point for signal integration in vascular smooth
muscle cells (VSMC) influencing contractile state and cellular responses to vessel wall injury. …

Early differences in hemodynamic variables and vasoactive substances between progeny
of hypertensive and normotensive parents were sought in normotensive children aged 10-17 …

… Lanier, and Jerry G. Webb. Adenylyl cyclase isoforms and vasopressin … occupation of
receptors that activate the stimulatory guanine nucleotide binding protein G,. The activated form of …

Volume overload congestive heart failure in dogs is associated with a reduced myocardial
inotropic responsiveness to the exogenous administration of β-adrenergic agonists [10, 11]. …

A highly enriched sarcolemma preparation was isolated by a combination of homogenizations
and differential centrifugations of a homogenate of canine ventricular tissue followed by …

The kallikrein/kinin system uses two distinct serine proteases, plasma kallikrein and tissue
kallikrein, to yield bradykinin and Lys-bradykinin (kallidin) from specific substrate kininogens. …

Three patients with brainstem tumors had orthostatic hypotension as the major presenting
manifestation. Two patients had primary tumors that involved the dorsal medulla, pons, and …

Extensive research has provided few therapeutic agents for the treatment of septicemia.
Bradykinin, an endogenous vasodepressor hormone, is a key mediator in the hypotension seen …

The mechanism by which angiotensin II (ANG II) potentiates hormone-induced adenosine 3',5'-cyclic
monophosphate (cAMP) formation was studied in cultured rat vascular smooth …