Pulmonary delivery of therapeutic siRNA
Small interfering RNA (siRNA) has a huge potential for the treatment or prevention of various
lung diseases. Once the RNA molecules have successfully entered the target cells, they …
lung diseases. Once the RNA molecules have successfully entered the target cells, they …
[HTML][HTML] Effective mRNA pulmonary delivery by dry powder formulation of PEGylated synthetic KL4 peptide
Pulmonary delivery of messenger RNA (mRNA) has considerable potential as therapy or
vaccine for a range of lung diseases. Inhaled dry powder formulation of mRNA is particularly …
vaccine for a range of lung diseases. Inhaled dry powder formulation of mRNA is particularly …
[HTML][HTML] siRNA versus miRNA as therapeutics for gene silencing
JKW Lam, MYT Chow, Y Zhang, SWS Leung - Molecular Therapy-Nucleic …, 2015 - cell.com
Discovered a little over two decades ago, small interfering RNAs (siRNAs) and microRNAs (miRNAs)
are noncoding RNAs with important roles in gene regulation. They have recently …
are noncoding RNAs with important roles in gene regulation. They have recently …
Chitosan-based nanosystems and their exploited antimicrobial activity
Chitosan is a biodegradable and biocompatible natural polysaccharide that has a wide range
of applications in the field of pharmaceutics, biomedical, chemical, cosmetics, textile and …
of applications in the field of pharmaceutics, biomedical, chemical, cosmetics, textile and …
Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug
6-Diazo-5-oxo-l-norleucine (DON) is a glutamine antagonist that suppresses cancer cell
metabolism but concurrently enhances the metabolic fitness of tumor CD8 + T cells. DON …
metabolism but concurrently enhances the metabolic fitness of tumor CD8 + T cells. DON …
[BOOK][B] Endosomal escape pathways for non-viral nucleic acid delivery systems
Nucleic acids, including plasmid DNA (pDNA) and small interfering RNA (siRNA), are
potential therapeutic macromolecules that have been widely explored for the treatment or …
potential therapeutic macromolecules that have been widely explored for the treatment or …
[HTML][HTML] Pulmonary delivery of biological drugs
In the last decade, biological drugs have rapidly proliferated and have now become an
important therapeutic modality. This is because of their high potency, high specificity and …
important therapeutic modality. This is because of their high potency, high specificity and …
Oral transmucosal drug delivery for pediatric use
The formulation of medicines for children remains a challenge. An ideal pediatric formulation
must allow accurate dose administration and be in a dosage form that can be handled by …
must allow accurate dose administration and be in a dosage form that can be handled by …
Biomedical applications of amino acid-modified chitosans: a review
The presence of reactive primary amines in the backbone structure of chitosan, enables the
derivatisation with different functional groups and thereby improving and expanding its …
derivatisation with different functional groups and thereby improving and expanding its …
[HTML][HTML] Real-world outcomes of immunotherapy–based regimens in first-line advanced non-small cell lung cancer
D Waterhouse, J Lam, KA Betts, L Yin, S Gao, Y Yuan… - Lung Cancer, 2021 - Elsevier
Background First-line (1L) immunotherapy (IO) has improved outcomes in patients with
advanced non-small cell lung cancer (NSCLC) in clinical trials and is now routinely used alone …
advanced non-small cell lung cancer (NSCLC) in clinical trials and is now routinely used alone …