User profiles for Jenny Lam

Jenny Ka Wing Lam

- Verified email at ucl.ac.uk - Cited by 4397

Jenny Lam

- Verified email at nyu.edu - Cited by 371

Pulmonary delivery of therapeutic siRNA

JKW Lam, W Liang, HK Chan - Advanced drug delivery reviews, 2012 - Elsevier
Small interfering RNA (siRNA) has a huge potential for the treatment or prevention of various
lung diseases. Once the RNA molecules have successfully entered the target cells, they …

[HTML][HTML] Effective mRNA pulmonary delivery by dry powder formulation of PEGylated synthetic KL4 peptide

…, Q Liao, KLK Kung, MYT Chow, JKW Lam - Journal of controlled …, 2019 - Elsevier
Pulmonary delivery of messenger RNA (mRNA) has considerable potential as therapy or
vaccine for a range of lung diseases. Inhaled dry powder formulation of mRNA is particularly …

[HTML][HTML] siRNA versus miRNA as therapeutics for gene silencing

JKW Lam, MYT Chow, Y Zhang, SWS Leung - Molecular Therapy-Nucleic …, 2015 - cell.com
Discovered a little over two decades ago, small interfering RNAs (siRNAs) and microRNAs (miRNAs)
are noncoding RNAs with important roles in gene regulation. They have recently …

Chitosan-based nanosystems and their exploited antimicrobial activity

DR Perinelli, L Fagioli, R Campana, JKW Lam… - European Journal of …, 2018 - Elsevier
Chitosan is a biodegradable and biocompatible natural polysaccharide that has a wide range
of applications in the field of pharmaceutics, biomedical, chemical, cosmetics, textile and …

Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug

…, L Tenora, ML Arwood, A Pal, J Alt, Y Wu, J Lam… - Science …, 2022 - science.org
6-Diazo-5-oxo-l-norleucine (DON) is a glutamine antagonist that suppresses cancer cell
metabolism but concurrently enhances the metabolic fitness of tumor CD8 + T cells. DON …

[BOOK][B] Endosomal escape pathways for non-viral nucleic acid delivery systems

W Liang, JKW Lam - 2012 - books.google.com
Nucleic acids, including plasmid DNA (pDNA) and small interfering RNA (siRNA), are
potential therapeutic macromolecules that have been widely explored for the treatment or …

[HTML][HTML] Pulmonary delivery of biological drugs

W Liang, HW Pan, D Vllasaliu, JKW Lam - Pharmaceutics, 2020 - mdpi.com
In the last decade, biological drugs have rapidly proliferated and have now become an
important therapeutic modality. This is because of their high potency, high specificity and …

Oral transmucosal drug delivery for pediatric use

JKW Lam, Y Xu, A Worsley, ICK Wong - Advanced drug delivery reviews, 2014 - Elsevier
The formulation of medicines for children remains a challenge. An ideal pediatric formulation
must allow accurate dose administration and be in a dosage form that can be handled by …

Biomedical applications of amino acid-modified chitosans: a review

L Casettari, D Vllasaliu, JKW Lam, M Soliman, L Illum - Biomaterials, 2012 - Elsevier
The presence of reactive primary amines in the backbone structure of chitosan, enables the
derivatisation with different functional groups and thereby improving and expanding its …

[HTML][HTML] Real-world outcomes of immunotherapy–based regimens in first-line advanced non-small cell lung cancer

D Waterhouse, J Lam, KA Betts, L Yin, S Gao, Y Yuan… - Lung Cancer, 2021 - Elsevier
Background First-line (1L) immunotherapy (IO) has improved outcomes in patients with
advanced non-small cell lung cancer (NSCLC) in clinical trials and is now routinely used alone …