Phospholipases (PLAs) produce rate-limiting precursors in the biosynthesis of various types
of biologically active lipids involved in inflammatory processes. Increased levels of human …

The preceding papers of this series detail the development of functionalized indole-3-acetamides
as inhibitors of hnps-PLA 2 . We describe here the extension of the structure−activity …

As reported in our previous paper, a series of indole-3-acetamides which possessed
potency and selectivity as inhibitors of human nonpancreatic secretory phospholipase A 2 (hnps-…

Inhibition of glutamate carboxypeptidase (GCP) II (EC 3.4.17.21), also termed N-acetylated
alpha-linked acidic dipeptidase (NAALADase), has been shown to protect against ischemic …

N-acetylated-α-linked-acidic-dipeptidase (NAALADase or glutamate carboxypeptidase II)
cleaves the neuropeptide N-acetyl-aspartyl-glutamate (NAAG) to glutamate and N-acetyl-…

We previously reported that inhibition of the brain enzymeN-acetylated α-linked acidic
dipeptidase (NAALADase; glutamate carboxypeptidase II) robustly protects cortical neurons from …

The design, synthesis, and enzyme inhibitory profile of D-Phe-Pro-p-Amidinobenzylamine
are presented. This compound has inhibitory activity equivalent to D-Phe-Pro-Arg-H, two …

Analogs of D-Phe-Pro-Agmatine were assayed for inhibititory activity versus thrombin, trypsin,
plasmin, n-tPA and urokinase. The X-ray structure of the thrombin/D-Phe-Pro-Agmatine co-…

The addictive and euphorogenic properties of cocaine are thought to result from inhibition of
the dopamine transporter (DAT). Recent evidence suggests that dopamine and cocaine …

Folates have been shown to be neurotoxic and convulsive. Endogenously, folates exist in
the brain in a polyglutamated form with 1–7 terminal glutamates (approx. 1 μM). The brain …