Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis

JL Funk, JN Oyarzo, JB Frye, G Chen… - Journal of natural …, 2006 - ACS Publications
Turmeric has been used for centuries in Ayurvedic medicine as a treatment for inflammatory
disorders including arthritis. On the basis of this traditional usage, dietary supplements …

Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis

JL Funk, JB Frye, JN Oyarzo… - … : Official Journal of …, 2006 - Wiley Online Library
Objective Scientific evidence is lacking for the antiarthritic efficacy of turmeric dietary
supplements that are being promoted for arthritis treatment. Therefore, we undertook studies to …

Comparative Effects of Two Gingerol-Containing Zingiber officinale Extracts on Experimental Rheumatoid Arthritis

JL Funk, JB Frye, JN Oyarzo… - Journal of natural …, 2009 - ACS Publications
Ginger (Zingiber officinale) supplements are being promoted for arthritis treatment in western
societies on the basis of ginger’s traditional use as an anti-inflammatory in Chinese and …

Anti-Arthritic Effects and Toxicity of the Essential Oils of Turmeric (Curcuma longa L.)

JL Funk, JB Frye, JN Oyarzo, H Zhang… - Journal of agricultural …, 2010 - ACS Publications
Turmeric (Curcuma longa L., Zingiberaceae) rhizomes contain two classes of secondary
metabolites, curcuminoids and the less well-studied essential oils. Having previously identified …

Anti-inflammatory effects of the essential oils of ginger (Zingiber officinale Roscoe) in experimental rheumatoid arthritis

JL Funk, JB Frye, JN Oyarzo, J Chen, H Zhang… - PharmaNutrition, 2016 - Elsevier
Ginger and its extracts have been used traditionally as anti-inflammatory remedies, with a
particular focus on the medicinal properties of its phenolic secondary metabolites, the …

Bioactivity of turmeric-derived curcuminoids and related metabolites in breast cancer

LE Wright, JB Frye, B Gorti… - Current …, 2013 - ingentaconnect.com
While the chemotherapeutic effect of curcumin, one of three major curcuminoids derived from
turmeric, has been reported, largely unexplored are the effects of complex turmeric extracts …

[HTML][HTML] Multiplex immunoassay characterization and species comparison of inflammation in acute and non-acute ischemic infarcts in human and mouse brain tissue

TVV Nguyen, JB Frye, JC Zbesko, K Stepanovic… - Acta neuropathologica …, 2016 - Springer
This study provides a parallel characterization of the cytokine and chemokine response to
stroke in the human and mouse brain at different stages of infarct resolution. The study goal …

Increased manganese superoxide dismutase expression or treatment with manganese porphyrin potentiates dexamethasone-induced apoptosis in lymphoma cells

MC Jaramillo, JB Frye, JD Crapo, MM Briehl, ME Tome - Cancer research, 2009 - AACR
Glucocorticoid-induced apoptosis is exploited for the treatment of hematologic malignancies.
Innate and acquired resistance limits treatment efficacy; however, resistance mechanisms …

Curcumin, but not curcumin-glucuronide, inhibits Smad signaling in TGFβ-dependent bone metastatic breast cancer cells and is enriched in bone compared to other …

AG Kunihiro, JA Brickey, JB Frye, PB Luis… - The Journal of nutritional …, 2019 - Elsevier
… , Julia A Brickey b , Jennifer B Frye b , Paula B Luis c , Claus Schneider c , Janet L Funk a b
… 3B), although these changes only reached statistical significance in the human breast cancer …

[HTML][HTML] Repeated administration of 2-hydroxypropyl-β-cyclodextrin (HPβCD) attenuates the chronic inflammatory response to experimental stroke

DA Becktel, JC Zbesko, JB Frye, AG Chung… - Journal of …, 2022 - Soc Neuroscience
Globally, more than 67 million people are living with the effects of ischemic stroke. Importantly,
many stroke survivors develop a chronic inflammatory response that may contribute to …