Serotonin2C receptors tonically suppress the activity of mesocortical dopaminergic and adrenergic, but not serotonergic, pathways: A combined dialysis and …
…, A Adhumeau‐Auclair, JP Nicolas… - Synapse, 2000 - Wiley Online Library
The present study evaluated, via a combined electrophysiological and dialysis approach, the
potential influence of serotonin (5‐HT) 2C as compared to 5‐HT 2A and 5‐HT 2B receptors …
potential influence of serotonin (5‐HT) 2C as compared to 5‐HT 2A and 5‐HT 2B receptors …
Comparative pharmacological studies of melatonin receptors: MT1, MT2 and MT3/QR2. Tissue distribution of MT3/QR2
O Nosjean, JP Nicolas, F Klupsch, P Delagrange… - Biochemical …, 2001 - Elsevier
The neurohormone melatonin is the central switch of the circadian rhythm and presumably
exerts its activities through a series of receptors among which MT 1 and MT 2 have been …
exerts its activities through a series of receptors among which MT 1 and MT 2 have been …
Agonist and antagonist actions of yohimbine as compared to fluparoxan at α2‐adrenergic receptors (AR) s, serotonin (5‐HT) 1A, 5‐HT1B, 5‐HT1D and dopamine D2 …
…, V Audinot, D Cussac, F Lejeune, JP Nicolas… - Synapse, 2000 - Wiley Online Library
Herein, we evaluate the interaction of the α 2 ‐AR antagonist, yohimbine, as compared to
fluparoxan, at multiple monoaminergic receptors and examine their roles in the modulation of …
fluparoxan, at multiple monoaminergic receptors and examine their roles in the modulation of …
Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. II. Agonist and antagonist properties at subtypes of dopamine D2-like …
…, D Cussac, V Audinot, JP Nicolas… - … of Pharmacology and …, 2002 - ASPET
The accompanying multivariate analysis of the binding profiles of antiparkinson agents
revealed contrasting patterns of affinities at diverse classes of monoaminergic receptor. Herein, …
revealed contrasting patterns of affinities at diverse classes of monoaminergic receptor. Herein, …
[HTML][HTML] Localization of structural elements of bee venom phospholipase A2 involved in N-type receptor binding and neurotoxicity
JP Nicolas, Y Lin, G Lambeau, F Ghomashchi… - Journal of Biological …, 1997 - ASBMB
We have shown previously that neurotoxic venom secretory phospholipases A 2 (sPLA 2 s)
have specific receptors in brain membranes called N-type receptors that are likely to play a …
have specific receptors in brain membranes called N-type receptors that are likely to play a …
Discovery and optimization of pyrimidone indoline amide PI3Kβ inhibitors for the treatment of phosphatase and tensin homologue (PTEN)-deficient cancers
…, L Vincent, H Bonnevaux, JP Nicolas… - Journal of medicinal …, 2014 - ACS Publications
Compelling molecular biology publications have reported the implication of phosphoinositide
kinase PI3Kβ in PTEN-deficient cell line growth and proliferation. These findings supported …
kinase PI3Kβ in PTEN-deficient cell line growth and proliferation. These findings supported …
Synthesis and Structure−Affinity−Activity Relationships of Novel Benzofuran Derivatives as MT2 Melatonin Receptor Selective Ligands
…, JA Boutin, V Audinot, JP Nicolas… - Journal of medicinal …, 2002 - ACS Publications
A series of N-(2-phenylbenzofuran-3-yl) ethyl amide and N-(2-arylalkylbenzofuran-3-yl)
ethyl amide derivatives were synthesized and evaluated as melatonin receptor ligands. The …
ethyl amide derivatives were synthesized and evaluated as melatonin receptor ligands. The …
Characterization of 2-[125I] iodomelatonin binding sites in Syrian hamster peripheral organs
P Paul, C Lahaye, P Delagrange, JP Nicolas… - … of Pharmacology and …, 1999 - ASPET
The neurohormone melatonin is a key agent in synchronizing the circadian rhythms. At least
three types of binding sites have been described for melatonin: the G-coupled, seven-…
three types of binding sites have been described for melatonin: the G-coupled, seven-…
[HTML][HTML] Structural Elements of Secretory Phospholipases A2 Involved in the Binding to M-type Receptors (∗)
G Lambeau, P Ancian, JP Nicolas, SHW Beiboer… - Journal of Biological …, 1995 - ASBMB
Specific membrane receptors for secretory phospholipases A 2 (sPLA 2 s) have been initially
identified with novel snake venom sPLA 2 s called OS 1 and OS 2 . One of these sPLA 2 …
identified with novel snake venom sPLA 2 s called OS 1 and OS 2 . One of these sPLA 2 …
Production of the bengamide class of marine natural products in myxobacteria: biosynthesis and structure–activity relationships
…, H Tietgen, D Schummer, JP Nicolas… - Angewandte Chemie …, 2015 - Wiley Online Library
The bengamides, sponge‐derived natural products that have been characterized as
inhibitors of methionine aminopeptidases (MetAPs), have been intensively investigated as …
inhibitors of methionine aminopeptidases (MetAPs), have been intensively investigated as …