Vascular protection by dietary polyphenols

JC Stoclet, T Chataigneau, M Ndiaye, MH Oak… - European journal of …, 2004 - Elsevier
Consumption of polyphenol-rich foods, such as fruits and vegetables, and beverages derived
from plants, such as cocoa, red wine and tea, may represent a beneficial diet in terms of …

[HTML][HTML] Resistance to endotoxic shock as a consequence of defective NF‐κB activation in poly (ADP‐ribose) polymerase‐1 deficient mice

…, S Muller, G de la Rubia, JC Stoclet… - The EMBO …, 1999 - embopress.org
Poly (ADP‐ribose) polymerase‐1 is a nuclear DNA‐binding protein that participates in the
DNA base excision repair pathway in response to genotoxic stress in mammalian cells. Here …

Nitric oxide production and endothelium‐dependent vasorelaxation induced by wine polyphenols in rat aorta

…, B Muller, A Beretz, JC Stoclet… - British Journal of …, 1997 - Wiley Online Library
The aim of this work was to investigate the mechanism of vasorelaxation induced by red
wine polyphenolic compounds (RWPC) and two defined polyphenols contained in wine, …

[HTML][HTML] Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxation in rat thoracic aorta

…, A Lobstein, R Anton, A Beretz, JC Stoclet… - The Journal of …, 1998 - Elsevier
This study investigated the possible active principles which support the endothelial nitric
oxide-dependent relaxation produced by red wine and other plant polyphenolic compounds in …

Nitric oxide transport and storage in the cardiovascular system

…, JL Alencar, A Vanin, JC STOCLET - Annals of the New …, 2002 - Wiley Online Library
Despite short halflife in biological fluids, nitric oxide (NO) can produce remote or long lasting
effect in the cardiovascular system. Long distance transport or local storage of NO might …

A human tissue‐engineered vascular media: a new model for pharmacological studies of contractile responses

N L'HEUREUX, JC STOCLET, FA AUGER… - The FASEB …, 2001 - Wiley Online Library
Our method for producing tissue‐engineered blood vessels based exclusively on the use of
human cells, ie, without artificial scaffolding, has previously been described (1). In this report…

Vascular bed heterogeneity in age‐related endothelial dysfunction with respect to NO and eicosanoids

…, MA De Sotomayor, C Schott, JC Stoclet… - British journal of …, 2000 - Wiley Online Library
Endothelial dysfunction has been described with ageing but the mechanisms responsible
have not been clearly elucidated and might be different from one vessel to the other. This …

Section Review: Cardiovascular & Renal: Cyclic nucleotide phosphodiesterases as therapeutic targets in cardiovascular diseases

JC Stoclet, T Keravis, N Komas… - Expert Opinion on …, 1995 - Taylor & Francis
Cyclic nucleotide phosphodiesterases (PDEs) comprise at least seven families of isozymes
coded by related but distinct genes, grouped on the basis of their structural and enzymatic …

Endothelium‐dependent and independent relaxation of the rat aorta by cyclic nucleotide phosphodiesterase inhibitors

N Komas, C Lugnier, JC Stoclet - British journal of …, 1991 - Wiley Online Library
1 The effects of selective inhibitors of adenosine 3′: 5′‐cyclic monophosphate (cyclic
AMP) and guanosine 3′: 5′‐cyclic monophosphate (cyclic GMP) phosphodiesterases (PDEs) …

Mechanism of endothelial nitric oxide-dependent vasorelaxation induced by wine polyphenols in rat thoracic aorta

E Andriambeloson, JC Stoclet… - Journal of …, 1999 - journals.lww.com
The mechanisms by which red wine polyphenolic compounds (RWPCs) induced
endothelium-dependent relaxation were investigated in rat thoracic aorta rings with endothelium. …