Structure− activity studies of substituted quinoxalinones as multiple-drug-resistance antagonists
DS Lawrence, JE Copper, CD Smith - Journal of medicinal …, 2001 - ACS Publications
A significant problem in the clinical treatment of cancer relates to the development of tumor
resistance to many chemotherapeutic agents. Acquired drug resistance is often mediated …
resistance to many chemotherapeutic agents. Acquired drug resistance is often mediated …
Computational 3D histological phenotyping of whole zebrafish by X-ray histotomography
10.7554/eLife.44898.001 Organismal phenotypes frequently involve multiple organ systems.
Histology is a powerful way to detect cellular and tissue phenotypes, but is largely …
Histology is a powerful way to detect cellular and tissue phenotypes, but is largely …
[HTML][HTML] Comparative analysis of fixation and embedding techniques for optimized histological preparation of zebrafish
JE Copper, LR Budgeon, CA Foutz… - … and Physiology Part C …, 2018 - Elsevier
In recognition of the importance of zebrafish as a model organism for studying human disease,
we have created zebrafish content for a web-based reference atlas of microanatomy for …
we have created zebrafish content for a web-based reference atlas of microanatomy for …
Cyclohexyl-octahydro-pyrrolo [1, 2-a] pyrazine-based inhibitors of human N-myristoyltransferase-1
…, Y Zhuang, RS Schrecengost, JE Copper… - … of Pharmacology and …, 2004 - ASPET
N-Myristoyltransferase (NMT) is an emerging therapeutic target that catalyzes the attachment
of myristate to the N terminus of an acceptor protein. We have developed a medium-…
of myristate to the N terminus of an acceptor protein. We have developed a medium-…
New jaspamide derivatives with antimicrofilament activity from the sponge Jaspis splendans
…, S De Marino, F Zollo, CD Smith, JE Copper… - Tetrahedron, 2007 - Elsevier
A reinvestigation of Jaspis splendans afforded the novel compounds jaspamide D–G plus
the known compounds jaspamide and jaspamides B and C. All compounds exhibited potent …
the known compounds jaspamide and jaspamides B and C. All compounds exhibited potent …
Jaspamides H–L, new actin-targeting depsipeptides from the sponge Jaspis splendans
Continued investigation of cytotoxic extracts of the marine sponge Jaspis splendans has
resulted in the discovery of jaspamides H–L (2–5). Their structures were determined by …
resulted in the discovery of jaspamides H–L (2–5). Their structures were determined by …
Discovery of novel antitumor antimitotic agents that also reverse tumor resistance
A Gangjee, J Yu, JE Copper… - Journal of medicinal …, 2007 - ACS Publications
We have discovered a novel series of 7-benzyl-4-methyl-5-[(2-substituted phenyl)ethyl]-7H-pyrrolo[2,3-d]pyrimidin-2-amines,
which possess antimitotic and antitumor activities against …
which possess antimitotic and antitumor activities against …
Rigid embedding of fixed and stained, whole, Millimeter-Scale specimens for Section-free 3D histology by Micro-Computed tomography
…, DP Clark, D Mandrell, JE Copper… - JoVE (Journal of …, 2018 - jove.com
For over a hundred years, the histological study of tissues has been the gold standard for
medical diagnosis because histology allows all cell types in every tissue to be identified and …
medical diagnosis because histology allows all cell types in every tissue to be identified and …
A web-based histology atlas for the freshwater Cladocera species Daphnia magna
MS Ngu, DJ Vanselow, CR Zaino, AY Lin, JE Copper… - bioRxiv, 2022 - biorxiv.org
Daphnia are keystone species of freshwater habitats used as model organisms in ecology
and evolution. They are also routinely used as environmental sentinels in regulatory …
and evolution. They are also routinely used as environmental sentinels in regulatory …
Synthesis, conformational analysis, and cytotoxicity of new analogues of the natural cyclodepsipeptide jaspamide
…, I Bruno, G Bifulco, JE Copper… - Journal of natural …, 2004 - ACS Publications
Three analogues of the natural bioactive cyclodepsipeptide jaspamide (3−5) were efficiently
synthesized using a combination of solid and solution phase techniques. The preliminary …
synthesized using a combination of solid and solution phase techniques. The preliminary …