[HTML][HTML] Chronic treatment with the γ-secretase inhibitor LY-411,575 inhibits β-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

…, T Bara, L Engstrom, M Pinzon-Ortiz, JS Fine… - Journal of Biological …, 2004 - ASBMB
Inhibition of γ-secretase, one of the enzymes responsible for the cleavage of the amyloid
precursor protein (APP) to produce the pathogenic β-amyloid (Aβ) peptides, is an attractive …

[PDF][PDF] Single-cell analysis of Crohn's disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy

…, JS Fine, CE Whitehurst, ML Mbow, S Kugathasan… - Cell, 2019 - cell.com
Clinical benefits of cytokine blockade in ileal Crohn's disease (iCD) are limited to a subset
of patients. Here, we applied single-cell technologies to iCD lesions to address whether …

[HTML][HTML] Phoenix from the flames: Rediscovering the role of the CD40–CD40L pathway in systemic lupus erythematosus and lupus nephritis

…, J Steffgen, S Visvanathan, C Mohan, JS Fine… - Autoimmunity …, 2020 - Elsevier
Lupus nephritis (LN) is a significant complication of systemic lupus erythematosus (SLE),
increasing its morbidity and mortality. Although the current standard of care helps suppress …

[HTML][HTML] Bleomycin induces molecular changes directly relevant to idiopathic pulmonary fibrosis: a model for “active” disease

…, Z Liang, CM Hogaboam, C Kitson, DC Budd, JS Fine… - PloS one, 2013 - journals.plos.org
The preclinical model of bleomycin-induced lung fibrosis, used to investigate mechanisms
related to idiopathic pulmonary fibrosis (IPF), has incorrectly predicted efficacy for several …

[HTML][HTML] Inflammatory Signals shift from adipose to liver during high fat feeding and influence the development of steatohepatitis in mice

…, D Kinsley, L Cui, JS Fine, S Greenfeder… - Journal of …, 2011 - Springer
Background Obesity and inflammation are highly integrated processes in the pathogenesis
of insulin resistance, diabetes, dyslipidemia, and non-alcoholic fatty liver disease. Molecular …

RN486, a selective Bruton's tyrosine kinase inhibitor, abrogates immune hypersensitivity responses and arthritis in rodents

…, Y Lou, RJ Hill, S Narula, J DeMartino, JS Fine - … of Pharmacology and …, 2012 - ASPET
Genetic mutation and pharmacological inhibition of Bruton's tyrosine kinase (Btk) both have
been shown to prevent the development of collagen-induced arthritis (CIA) in mice, …

A novel, orally active CXCR1/2 receptor antagonist, Sch527123, inhibits neutrophil recruitment, mucus production, and goblet cell hyperplasia in animal models of …

…, R Bond, W Gonsiorek, MM Billah, JS Fine… - … of Pharmacology and …, 2007 - ASPET
Sch527123 [2-hydroxy-N,N-dimethyl-3-[[2-[[1(R)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]ben-zamide]
is a potent, selective antagonist of the human …

A novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist blocks leukocyte recruitment in vivo

CA Lunn, JS Fine, A Rojas-Triana, JV Jackson… - … of Pharmacology and …, 2006 - ASPET
The expression of the cannabinoid peripheral cannabinoid receptor (CB 2 ) receptor on
peripheral immune cells suggests that compounds specific for CB 2 might be effective anti-…

[HTML][HTML] Systemic biomarkers of neutrophilic inflammation, tissue injury and repair in COPD patients with differing levels of disease severity

…, KC Müller, O Holz, H Magnussen, H Watz, JS Fine - PloS one, 2012 - journals.plos.org
The identification and validation of biomarkers to support the assessment of novel therapeutics
for COPD continues to be an important area of research. The aim of the current study was …

[PDF][PDF] A selective and potent CXCR3 antagonist SCH 546738 attenuates the development of autoimmune diseases and delays graft rejection

…, S Qian, SH Kim, S Rosenblum, J Kozlowski, JS Fine… - BMC immunology, 2012 - Springer
Background The CXCR3 receptor and its three interferon-inducible ligands (CXCL9,
CXCL10 and CXCL11) have been implicated as playing a central role in directing a Th1 …