Serotonin (5-hydroxytryptamine, 5-HT) is probably unique among the monoamines in that its
effects are subserved by as many as 13 distinct heptahelical, G-protein-coupled receptors (…

Somatostatin (SRIF, somatotropin release inhibiting factor), discovered for its inhibitory action
on growth hormone (GH) secretion from pituitary, is an abundant neuropeptide. Two forms, …

We have explored the role of allergen sensitization and challenge in defining the response
of the airways of the Brown Norway (BN) rat to adenosine. In naïve animals or in rats …

We have investigated the effect of wortmannin, a potent and selective inhibitor of
phosphatidylinositol-3-kinase, on the immediate-type allergic response and the late phase …

The effects of 3-(3-iodo-4-aminobenzyl)-8-(4-oxyacetate)-1-propylxanthine (I-ABOPX; BW-A522),
which has nanomolar affinity for the recently cloned human and sheep adenosine A 3 …

We have recently demonstrated a marked and selective augmentation of the bronchoconstrictor
response to adenosine in actively sensitised Brown Norway (BN) rats challenged with …

Dexamethasone increases the expression of adenosine A 3 receptors and augments
degranulation in response to their activation in the rat basophilic leukemia cell line, RBL-2H3. We …

The bronchoconstrictor response to adenosine in the actively sensitised Brown Norway rat
is markedly augmented following low level allergen (ovalbumin) challenge. The response …

We describe a new experimental animal model which mimics closely the bronchoconstrictor
effects of adenosine in asthmatics. Brown Norway (BN) rats were sensitized to ovalbumin (…

Somatostatin (SST; SRIF-somatotrophin release inhibiting factor) produced by neuronal ‚neuroendocrine
‚inflammatory ‚immune cells and tumours ‚regulates its many (patho)-…