The prostaglandins are a family of lipids, originally discovered over 30 years ago in human
seminal fluid, which have since been found not only to have a wide variety of striking …

An operant behavioral study on morphine addiction utilized a self-injection technique for
giving intravenous injections to relatively unrestrained rats. The rate of self-injection varied …

A total 31 psychoactive drugs were offered to groups of naive rats for IV self-administration
and an injection rate greater than that for rats offered only saline indicated reinforcement. Two …

… beyond the joint allows a duct or vessel many weeks. … the cannula described by Weeks
(3) would remain functional for injections many weeks, blood could seldom be withdrawn …

Publisher Summary This chapter discusses long-term intravenous infusion. Long-term
intravenous infusions or frequent intermittent injections require that the animals be un-…

Method is described whereby polyethylene tubes, permanently implanted in aorta, may be
used routinely for repeated direct measurement of arterial pressure in un-anesthetized rats.

A complete cycle of morphine addiction (induction of tolerance and physical dependence,
self-maintenance by intravenous injections and abrupt withdrawal) was studied in rats …

Interactions of prostaglandin E 1 (PGE 1 ) with morphine have been reported in several test
systems and an hypothesis has been advanced for a role of prostaglandins in morphine …

The biological activity of the (15S)-15-methyl analogs of prostaglandin (PG) E 2 methyl ester
and PGF 2α methyl ester were compared in vitro on the isolated gerbil colon and rat uterus …

The reinforcing activity of 31 psychoactive drugs was evaluated. Drugs were offered by
intravenous self-administration to groups of naive rats. Reinforcement is indicated by an injection …