CYP3A proteins comprise a significant portion of the hepatic cytochrome P450 (CYP) protein
and they metabolize aroud 50% of drugs currently in use. The dissection of the individual …

The xenobiotic metabolizing cytochromes P450 (P450s) are among the most versatile
biological catalysts known, but knowledge of the structural basis for their broad substrate …

The genetic component of the inter-individual variability in CYP3A4 activity has been estimated
to be between 60% and 90%, but the underlying genetic factors remain largely unknown. …

A 1.9-Å molecular structure of the microsomal cytochrome P450 2B4 with the specific
inhibitor 4-(4-chlorophenyl)imidazole (CPI) in the active site was determined by x-ray …

Cytochrome P450 3A4 is generally considered to be the most important human drug-metabolizing
enzyme and is known to catalyze the oxidation of a number of substrates in a …

The RACE amplification technology was used on a novel CYP3A-like exon 1 sequence
detected during the reverse transcriptase/polymerase chain reaction analysis of human CYP3A …

Midazolam (MDZ) oxidation by recombinant CYP3A4 purified fromEscherichia coli and 30
mutants generated at 15 different substrate recognition site positions has been studied to …

Amphiphile selection is a critical step for structural studies of membrane proteins (MPs). We
have developed a family of steroid-based facial amphiphiles (FAs) that are structurally …

To better understand ligand-induced structural transitions in cytochrome P450 2B4, protein-ligand
interactions were investigated using a bulky inhibitor. Bifonazole, a broad spectrum …

Cytochrome P450 3A4 (CYP3A4) catalyzes the initial step in the clearance of many
pharmaceuticals and foreign chemicals. The structurally diverse nature of CYP3A4 substrates …