Pancreatic stellate cells (PSC) are a subset of pancreatic cancer-associated fibroblasts.
These cells provide prosurvival signals to tumors; however, little is known regarding their …

Integration is essential for HIV-1 replication, and the viral integrase (IN) protein is an important
therapeutic target. Allosteric IN inhibitors (ALLINIs) that engage the IN dimer interface at …

The potent HIV-1 capsid inhibitor GS-6207 is an investigational principal component of long-acting
antiretroviral therapy. We found that GS-6207 inhibits HIV-1 by stabilizing and …

The multifunctional HIV-1 enzyme integrase interacts with viral DNA and its key cellular cofactor
LEDGF to effectively integrate the reverse transcript into a host cell chromosome. These …

This paper presents the effect of additives on the mechanism and selectivity of the SmI 2 -mediated
coupling of alkyl halides and ketones. The reaction of 1-iodobutane and 2-octanone …

The first total synthesis of racemic perophoramidine is described. The key step features the
highly stereoselective introduction of the vicinial quaternary centers via base-promoted …

Hypermethylation of 5′-cytosine-guanosine islands of tumor suppressor genes resulting in
their silencing has been proposed to be a hallmark of various tumors. Modulation of DNA …

Two series of curcumin analogues, a total of twenty-four compounds, were synthesized and
evaluated. The most potent compound, compound 23, showed potent growth inhibitory …

While an essential role of HIV-1 integrase (IN) for integration of viral cDNA into human
chromosome is established, studies with IN mutants and allosteric IN inhibitors (ALLINIs) have …

… Woodard moved to the Division of Medicinal Chemistry and Pharmacognosy at The Ohio
State University where he joined the laboratory of Dr James R. Fuchs. Mr. Woodard's research …