The buprenorphine analogue BU10119 attenuates drug-primed and stress-induced cocaine reinstatement in mice

TM Hillhouse, KM Olson, JE Hallahan… - … of Pharmacology and …, 2021 - ASPET
There are no Food and Drug Administration–approved medications for cocaine use disorder,
including relapse. The μ-opioid receptor (MOPr) partial agonist buprenorphine alone or in …

Delta opioid receptor-mediated antidepressant-like effects of diprenorphine in mice

…, GE Burgess, JL West, JE Hallahan… - … of Pharmacology and …, 2023 - ASPET
Major depressive disorder is a highly common disorder, with a lifetime prevalence in the
United States of approximately 21%. Traditional antidepressant treatments are limited by a …

Gpt-neox-20b: An open-source autoregressive language model

S Black, S Biderman, E Hallahan, Q Anthony… - arXiv preprint arXiv …, 2022 - arxiv.org
We introduce GPT-NeoX-20B, a 20 billion parameter autoregressive language model trained
on the Pile, whose weights will be made freely and openly available to the public through a …

DNA-dependent protein kinase Is a molecular target for the development of noncytotoxic radiation–sensitizing drugs

…, J Halbrook, EA Kesicki, A Kashishian, DE Hallahan - Cancer research, 2005 - AACR
DNA-dependent protein kinase (DNA-PK)–defective severe combined immunodeficient (SCID)
mice have a greater sensitivity to ionizing radiation compared with wild-type mice due to …

Cytosolic phospholipase A2 and lysophospholipids in tumor angiogenesis

…, EM Yazlovitskaya, DE Hallahan - Journal of the National …, 2010 - academic.oup.com
Background Lung cancer and glioblastoma multiforme are highly angiogenic and, despite
advances in treatment, remain resistant to therapy. Cytosolic phospholipase A2 (cPLA 2 ) …

[HTML][HTML] Valproic acid enhances the efficacy of radiation therapy by protecting normal hippocampal neurons and sensitizing malignant glioblastoma cells

…, AN Hallahan, TA DeWees, A Laszlo, DE Hallahan - Oncotarget, 2015 - ncbi.nlm.nih.gov
Neurocognitive deficits are serious sequelae that follow cranial irradiation used to treat patients
with medulloblastoma and other brain neoplasms. Cranial irradiation causes apoptosis …

Identification of a Carboxyl group at the Active Site of Barley MaIt Phosphatase

…, MW Ganfield, ME Hallahan… - Proceedings of the …, 1965 - scholarworks.uni.edu
The dependence of the maximal velocity, V m with pH for barley malt phosphatase has
been studied from pH 4.0 to 5.4. The data show that an ionizable group in the enzyme-substrate …

[HTML][HTML] Blocking the functional domain of TIP1 by antibodies sensitizes cancer to radiation therapy

…, M Saikia, R Townsend, D Thotala, DE Hallahan… - Biomedicine & …, 2023 - Elsevier
Non-small-cell lung cancer (NSCLC) and glioblastoma (GB) have poor prognoses.
Discovery of new molecular targets is needed to improve therapy. Tax interacting protein 1 (TIP1), …

[HTML][HTML] Autotaxin and LPA receptors represent potential molecular targets for the radiosensitization of murine glioma through effects on tumor vasculature

…, R Hu, KM Leahy, EM Yazlovitskaya, DE Hallahan - PloS one, 2011 - journals.plos.org
Despite wide margins and high dose irradiation, unresectable malignant glioma (MG) is
less responsive to radiation and is uniformly fatal. We previously found that cytosolic …

Two prostate carcinoma cell lines demonstrate abnormalities in tumor suppressor genes

SJ Rubin, DE Hallahan, CR Ashman… - Journal of surgical …, 1991 - Wiley Online Library
Two prostate carcinoma cell lines, DU‐145 and PC‐3, were examined for abnormalities in the
retinoblastoma (Rb) and the p53 putative tumor suppressor genes. We found an abnormal …